ArticleHuman brain mapping2017
Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Intelligence, motoric and psychological outcomes in children from different ART treatments: a systematic review and meta-analysis.Journal of neurodevelopmental disorders · 2023Pooled it
- A systematic review of neuroimaging epigenetic research: calling for an increased focus on development.Molecular psychiatry · 2023Pooled it
- DNA methylation and brain structure and function across the life course: A systematic review.Neuroscience and biobehavioral reviews · 2020Pooled it
- Associations between body size, nutrition and socioeconomic position in early life and the epigenome: A systematic review.PloS one · 2018Pooled it
- Twin differences in lateral ventricle size accompany twin differences in phonological decoding.Brain structure & function · 2025Article
- Linking pregnancy- and birth-related risk factors to a multivariate fusion of child cortical structure.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Linking Pregnancy- and Birth-Related Risk Factors to a Multivariate Fusion of Child Cortical Structure.bioRxiv : the preprint server for biology · 2025Article
- Birth weight discordance, gene expression, and DNA methylation: A scoping review of epigenetic twin studies.PloS one · 2025Article
- Article
- Very Early-Life Risk Factors for Developing Dementia: Evidence From Full Population Registers.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Genetics and voice production in childhood and adolescence - a review.International journal of pediatrics & adolescent medicine · 2022Article
- Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins.Human brain mapping · 2020Article
- Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.Translational psychiatry · 2018Article
- Applying behavior change techniques to weight management during pregnancy: Impact on perinatal outcomes.Preventive medicine · 2017Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundSeveral studies have shown that the in utero environment, which can be indexed by birth weight (BW), is associated with cortical morphology in adolescence and adulthood. Work in monozygotic (MZ) twins suggests that this association is driven by non-shared environmental factors. This correlation could be the result of in utero impacts on DNA methylation. The aim of the present study with MZ twins is to replicate the association between discordance in BW and brain morphology and test whether discordance in DNA methylation mediates this relationship.
methodsOne hundred and four adolescent MZ twins (52 pairs, of which 42% were male pairs) who have been followed regularly since birth underwent T1 weighted structural MRI, and epigenome-wide assessment of DNA methylation from saliva at age 15.
resultsCo-twins had very similar measures of DNA methylation and cortical morphology. Higher BW members of a twin pair had increased total cortical surface area, and decreased cortical thickness compared to their lower BW sibling. BW Discordance was positively associated with both cortical surface area and cortical volume discordance. Genes involved in neurodevelopment were tentatively identified as mediators of both the BW - cortical volume, and BW- cortical surface area relationships.
conclusionsThe association between BW and cortical morphology in adolescence appears to be attributable to in utero environmental effects, and DNA methylation may play a role in mediating this relationship. Hum Brain Mapp 38:2037-2050, 2017. © 2017 Wiley Periodicals, Inc.
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