Observational studyJournal of veterinary internal medicine2017
The Utility of Acute-Phase Proteins in the Assessment of Treatment Response in Dogs With Bacterial Pneumonia.
Observational study in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Successful Management of Recurrent Hemoptysis, Polycythemia and Respiratory Distress in a Dog.Animals : an open access journal from MDPI · 2026Article
- The diagnostic performance of point-of-care tests for serum amyloid A and C-reactive protein in lame sows.Acta veterinaria Scandinavica · 2026Article
- The comparison of acute phase proteins in experimentally induced canine acute pancreatitis.BMC veterinary research · 2026Article
- Plasma C-reactive protein and interleukin-6 concentrations in foals during health and respiratory disease.Equine veterinary journal · 2026Article
- Evaluation of amyloid A and haptoglobin in the serum of cats with respiratory diseases.Frontiers in veterinary science · 2026Article
- Predictive Prognosis Value of CRP Measurement and CAR in Dogs Infected with Parvovirus.Veterinary sciences · 2025Article
- Investigation of the Correlation Between ELISA and Serum Amyloid A in the Diagnosis of Bordetella bronchiseptica in Dogs.Veterinary medicine and science · 2025Article
- Recognition and Diagnosis of Underlying Disease Processes in Bacterial Pneumonia.Animals : an open access journal from MDPI · 2024Review
- Relationship between Respiratory Rate, Oxygen Saturation, and Blood Test Results in Dogs with Chronic or Acute Respiratory Disease: A Retrospective Study.Veterinary sciences · 2024Article
- Evaluation of serum 25-hydroxyvitamin D, C-reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis.Journal of veterinary internal medicine · 2023Article
- Evaluation of Host Constitutive and Ex Vivo Coccidioidal Antigen-Stimulated Immune Response in Dogs with Naturally Acquired Coccidioidomycosis.Journal of fungi (Basel, Switzerland) · 2023Article
- Serum 25-hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease.Journal of veterinary internal medicine · 2023Article
- Apolipoprotein A1 and serum amyloid A in dogs with sepsis and septic shock.Frontiers in veterinary science · 2023Article
- Isolation of Oral Bacteria, Measurement of the C-Reactive Protein, and Blood Clinical Parameters in Dogs with Oral Tumor.Veterinary medicine international · 2023Article
- C-Reactive Protein as a Diagnostic Marker in Dogs: A Review.Animals : an open access journal from MDPI · 2022Review
- Association between quantitative bacterial culture of bronchoalveolar lavage fluid and antibiotic requirement in dogs with lower respiratory tract signs.Journal of veterinary internal medicine · 2022Article
- Serial evaluation of thoracic radiographs and acute phase proteins in dogs with pneumonia.Journal of veterinary internal medicine · 2022Article
- SeronegativeVeterinary sciences · 2022Article
- Acute phase protein response and changes in lipoprotein particle size in dogs with systemic inflammatory response syndrome.Journal of veterinary internal medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute-phase proteins (APPs) are sensitive markers of inflammation, and serum C-reactive protein (CRP) recently has been shown to be a useful diagnostic marker in dogs with bacterial pneumonia (BP). In humans with community-acquired pneumonia, APPs also have great utility as follow-up markers aiding in the assessment of treatment response.
objectivesThe aim of our study was to investigate the applicability of APPs as markers of treatment response in dogs with BP. ANIMALS: Nineteen dogs diagnosed with BP and 64 healthy dogs.
methodsThe study was conducted as a prospective longitudinal observational study. Serum CRP, serum amyloid A (SAA), and haptoglobin concentrations were followed during a natural course of BP. Normalization of serum CRP was used to guide the duration of antibiotic treatment (treatment was stopped 5-7 days after CRP normalized) in 8 of 17 dogs surviving to discharge; 9 of 17 dogs were treated according to conventional recommendations.
resultsAll measured APPs initially were significantly increased, but the magnitude of increase was not correlated to disease severity. C-reactive protein and SAA concentrations decreased rapidly after initiation of antimicrobial treatment. When normalization of serum CRP was used to guide the duration of antibiotic treatment, treatment duration was significantly (P = .015) decreased without increasing the number of relapses. CONCLUSIONS AND CLINICAL IMPORTANCE: Serum CRP and SAA reflected the recovery process well and therefore may be used as markers of treatment response. According to the results, the normalization of serum CRP may be used to guide the duration of antibiotic treatment in dogs with BP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.