Trial reportThe Journal of physiology2017
The effect of α
Trial report in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The Methodological Quality of Studies Investigating the Acute Effects of Exercise During Hypoxia Over the Past 40 years: A Systematic Review.Frontiers in physiology · 2022Pooled it
- Effects of continuous hypoxia on flow-mediated dilation in the cerebral and systemic circulation: on the regulatory significance of shear rate phenotype.The journal of physiological sciences : JPS · 2022Trial
- The independent effects of hypovolaemia and pulmonary vasoconstriction on ventricular function and exercise capacity during acclimatisation to 3800 m.The Journal of physiology · 2019Trial
- UBC-Nepal Expedition: acute alterations in sympathetic nervous activity do not influence brachial artery endothelial function at sea level and high altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Is resting muscle sympathetic nerve activity related to peripheral or cerebrovascular haemodynamics at high altitude? A retrospective analysis.Experimental physiology · 2026Article
- Cerebrovascular flow-mediated dilation in humans: Methodological challenges, physiological interpretation and future integrations.Experimental physiology · 2026Review
- Contribution of sympathetic nervous system activation to endothelial ischemia reperfusion injury in healthy adults.Physiological reports · 2025Article
- Lower glycemia levels in subjects with excessive erythrocytosis during the oral glucose tolerance test living in conditions of severe hypoxia.Frontiers in physiology · 2024Article
- Pharmacological modulation of adrenergic tone alters the vasodilatory response to passive leg movement in young but not in old adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2021Article
- Global Reach 2018 Heightened α-Adrenergic Signaling Impairs Endothelial Function During Chronic Exposure to Hypobaric Hypoxia.Circulation research · 2020Article
- Review
- Population History and Altitude-Related Adaptation in the Sherpa.Frontiers in physiology · 2019Review
- UBC-Nepal Expedition: imposed oscillatory shear stress does not further attenuate flow-mediated dilation during acute and sustained hypoxia.American journal of physiology. Heart and circulatory physiology · 2018Article
- Article
- Measuring high-altitude adaptation.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsOur objective was to quantify endothelial function (via brachial artery flow-mediated dilatation) at sea level (344 m) and high altitude (3800 m) at rest and following both maximal exercise and 30 min of moderate-intensity cycling exercise with and without administration of an α ABSTRACT: We examined the hypotheses that (1) at rest, endothelial function would be impaired at high altitude compared to sea level, (2) endothelial function would be reduced to a greater extent at sea level compared to high altitude after maximal exercise, and (3) reductions in endothelial function following moderate-intensity exercise at both sea level and high altitude are mediated via an α
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.