ArticleInternational journal of behavioral medicine2017
Comorbidity of Migraine, Major Depressive Disorder, and Generalized Anxiety Disorder in Adolescents and Young Adults.
Article in International journal of behavioral medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Association between migraine and cognitive impairment.The journal of headache and pain · 2022Pooled it
- Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications.The journal of headache and pain · 2019Pooled it
- Analysis of Sleep Quality and Its Associated Factors in Adolescents with Migraine.Journal of pain research · 2026Article
- Diagnosing migraine in children and adolescence using ID migraine: results of an Italian multicenter validation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Assessing volumetric brain differences in migraine and depression patients: a UK Biobank study.BMC neurology · 2023Article
- A population-health approach to characterizing migraine by comorbidity: Results from the Mindfulness and Migraine Cohort Study.Cephalalgia : an international journal of headache · 2022Article
- Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?Medicines (Basel, Switzerland) · 2022Review
- Patterns of Depression and Resilience in Children and Adolescents Exposed to an Earthquake: A Latent Profile Analysis.Psychiatry investigation · 2021Article
- Irritability and its relationships with psychological symptoms in adolescents with migraine: a case-control study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Anxiety, Depression, and Body Weight in Children and Adolescents With Migraine.Frontiers in psychology · 2020Article
- Onabotulinumtoxin A Improves Psychological Aspects in Chronic Migraine Patients.Frontiers in neurology · 2020Article
- Migraine, Cyclic Vomiting Syndrome, and Other Gastrointestinal Disorders.Current treatment options in gastroenterology · 2018Review
- Migraine and greater pain symptoms at 10-year follow-up among patients with major depressive disorder.The journal of headache and pain · 2018Article
- Article
- Is psychiatric morbidity in chronic migraine associated with poor outcome: Experience from a tertiary care centrer.Industrial psychiatry journalArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
purposeDepression and anxiety are highly comorbid psychiatric conditions and both are common in adult patients with migraine. This study aims to examine the unique associations between major depressive disorder (MDD) and generalized anxiety disorder (GAD) in a well-characterized group of older adolescents and college-age individuals with migraine.
methodParticipants (N = 227), between 15 and 20 years old, who were unmedicated or within 1 month of beginning antidepressant treatment underwent a comprehensive psychiatric assessment to establish the presence of MDD and GAD, according to the Diagnostic and Statistical Manual, Fourth Edition, Text Revision, and to rate their symptom severity using the Longitudinal Interval Follow-up Evaluation for Adolescents (A-LIFE). They then completed the ID-Migraine. The Student's t test and chi-square test were used to compare continuous and categorical variables, respectively, across participants with vs. without migraine. Logistic regression analysis examined the association between the presence of migraine and psychopathology.
resultsA diagnosis of MDD was associated with significantly increased risk of having migraine. Moreover, more severe and persistent ratings of depression were associated with an even higher likelihood of having migraine. A diagnosis of GAD was also significantly associated with the presence of migraine. The prevalence of comorbid MDD and GAD was significantly higher in participants with migraine than those without migraine (55 vs. 22%, p < 0.0001). When examined concurrently, GAD remained significantly associated with migraine, with a statistical trend for MDD to be associated with it.
conclusionThe comorbidity of migraine, MDD, and GAD has important clinical and research implications. Patients who suffer from any of these problems should be screened for all three in order to receive comprehensive care. Shared psychological and biological vulnerabilities may be involved in the three conditions. Greater understanding of the shared vulnerabilities can lead to unified treatments.
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