Evidence map›Paper›PMID 28032311›Full record

ArticlePathology oncology research : POR2017

Prognostic Factors for Renal Cell Carcinoma Subtypes Diagnosed According to the 2016 WHO Renal Tumor Classification: a Study Involving 928 Patients.

Levente Kuthi, Alex Jenei, Adrienn Hajdu, István Németh, Zoltán Varga, Zoltán Bajory, László Pajor, Béla Iványi

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Pathology oncology research : POR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Levente KuthiDepartment of Pathology, University of Szeged, Állomás Street 1, Szeged, H-6725, Hungary. kuthi.levente@med.u-szeged.hu.ORCID http://orcid.org/0000-0001-9247-6679
Alex JeneiDepartment of Pathology, University of Szeged, Állomás Street 1, Szeged, H-6725, Hungary.
Adrienn HajduDepartment of Pathology, University of Szeged, Állomás Street 1, Szeged, H-6725, Hungary.
István NémethDepartment of Dermatology and Allergology, University of Szeged, Korányi Alley 6, Szeged, H-6720, Hungary.
Zoltán VargaDepartment of Oncotherapy, University of Szeged, Korányi Alley 12, Szeged, H-6720, Hungary.
Zoltán BajoryDepartment of Urology, University of Szeged, Kálvária Lane 57, Szeged, H-6725, Hungary.
László PajorDepartment of Urology, University of Szeged, Kálvária Lane 57, Szeged, H-6725, Hungary.
Béla IványiDepartment of Pathology, University of Szeged, Állomás Street 1, Szeged, H-6725, Hungary.
University of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morphotype and grade of renal cell carcinoma (RCC) in 928 nephrectomies were reclassified according to the 2016 WHO classification in order to analyze the distribution and outcomes of RCC subtypes in Hungary, to assess whether microscopic tumor necrosis is an independent prognostic factor in clear cell RCC, and to study whether a two-tiered grading (low/high) for clear cell and papillary RCC provides similar prognostic information to that of the four-tiered ISUP grading system. 83.4% of the cohort were clear cell, 6.9% papillary, 4.5% chromophobe, 2.3% unclassified, 1.1% Xp11 translocation, 1.1% clear cell papillary, 0.3% collecting duct and 0.1% mucinous tubular and spindle cell RCCs. RCC occurred in 16 patients with end-stage kidney disease and none of them displayed features of acquired cystic kidney disease-associated RCC. The 5-year survival rates were as follows: chromophobe 100%, clear cell papillary 100%, clear cell low-grade 96%, papillary type 1 92%, clear cell high-grade 63%, papillary type 2 65%, unclassified 46%, Xp11 translocation 20%, and collecting duct 0%. The 5-year survival rates in low-grade and high-grade papillary RCC were 95% and 59%, respectively. In clear cell RCC, only the grade, the stage and the positive surgical margin proved to be independent prognostic factors statistically. Overall, papillary RCC occurred relatively infrequently; microscopic tumor necrosis in clear cell RCC did not predict the outcome independently of the tumor grading; and the assignment of clear cell and papillary RCCs into low-grade or high-grade tumors was in terms of survival no worse than the ISUP grading.

Indexed as

AdolescentAdultAgedAged, 80 and overCarcinoma, Renal CellChildFemaleHumansHungaryKidney NeoplasmsMaleMiddle AgedNeoplasm GradingPrognosisSurvival RateTranslocation, GeneticISUP gradingMicroscopic tumor necrosisPrognostic factorsRenal cell carcinomaSurvival rates

Identifiers

PMID28032311
OpenAlexW2564727553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.