Trial reportCognitive, affective & behavioral neuroscience2017
Neural circuitry of emotion regulation: Effects of appraisal, attention, and cortisol administration.
Trial report in Cognitive, affective & behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between brain activity and endogenous and exogenous cortisol - A systematic review.Psychoneuroendocrinology · 2020Pooled it
- Oxytocin moderates fMRI connectivity and response to implicit threat processing in cocaine use disorder.Psychoneuroendocrinology · 2025Trial
- Effect of lithium administration on brain activity under an emotion regulation paradigm in healthy participants: a functional magnetic resonance imaging study.Psychopharmacology · 2023Trial
- Sex-specific effects of low-dose hydrocortisone on threat detection in HIV.Journal of neurovirology · 2021Trial
- A single low dose of hydrocortisone enhances cognitive functioning in HIV-infected women.AIDS (London, England) · 2018Trial
- Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers.Psychiatry research. Neuroimaging · 2026Article
- Beyond physical isolation: behavioral correlates and potential neurobiological mechanisms of functional social isolation.Frontiers in psychology · 2026Review
- Older and wiser? The neural correlates of worry induction and reappraisal in older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Article
- Trauma Timing and Its Impact on Brain Activation During Flexible Emotion Regulation in PTSD: Insights From Functional MRI.Human brain mapping · 2025Article
- Aberrant brain network connectivity related to cognitive and emotional regulation in women with abdominal obesity.Scientific reports · 2025Article
- Frontocortical activity and emotional experience in the context of daily life events.Social cognitive and affective neuroscience · 2025Article
- The healing power ofFrontiers in psychology · 2025Article
- Guilt emotion and decision-making under uncertainty.Frontiers in psychology · 2025Article
- Puberty and NeuroDevelopment in adolescents (PANDA): a study protocol.BMC pediatrics · 2024Article
- Greater Early Posttrauma Activation in the Right Inferior Frontal Gyrus Predicts Recovery From Posttraumatic Stress Disorder Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Attention Circuits Mediate the Connection between Emotional Experience and Expression within the Emotional Circuit.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- A normative model of brain responses to social scenarios reflects the maturity of children and adolescents' social-emotional abilities.Social cognitive and affective neuroscience · 2023Article
- Influence of chronic stress on network states governing valence processing: Potential relevance to the risk for psychiatric illnesses.Journal of neuroendocrinology · 2023Review
- What a difference timing makes: Cortisol effects on neural underpinnings of emotion regulation.Neurobiology of stress · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Psychosocial well-being requires effective regulation of emotional responding in context of threat or stress. Neuroimaging studies have focused on instructed, volitional regulation (e.g., reappraisal or distancing), largely ignoring implicit regulation that does not involve purposeful effort to alter emotional experience. These implicit processes may or may not involve the same neural pathways as explicit regulatory strategies. We examined the neurobiology of implicit emotional regulation processes and the impact of the stress hormone cortisol on these processes. Our study task employed composite pictures of faces and places to examine neural activity during implicit emotional processing (of emotional faces), while these responses were implicitly regulated by attention shift away from the emotionally evocative stimuli, and while subjects reflectively appraised their own emotional response to them. Subjects completed the task in an fMRI scanner after random assignment to receive placebo or hydrocortisone (HCT), an orally administered version of cortisol. Implicit emotional processing activated insula/IFG, dACC/dMPFC, midbrain and amygdala. With attention shifting, we saw diminished signal in emotion generating/response regions (e.g., amygdala) and increased activations in task specific attention regions like parahippocampus. With appraisal of emotions, we observed robust activations in medial prefrontal areas, where activation is also seen in instructed reappraisal studies. We observed no main effects of HCT administration on brain, but males and females showed opposing neural effects in prefrontal areas. The data suggest that different types of emotion regulation utilize overlapping circuits, but with some strategy specific activation. Further study of the dimorphic sex response to cortisol is needed.
Indexed as
Identifiers
28032303What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.