ReviewDocumenta ophthalmologica. Advances in ophthalmology2017
Efferent influences on the bioelectrical activity of the retina in primates.
Review in Documenta ophthalmologica. Advances in ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Association between ADHD and vision problems. A systematic review and meta-analysis.Molecular psychiatry · 2023Pooled it
- The effect of human gene therapy for RPE65-associated Leber's congenital amaurosis on visual function: a systematic review and meta-analysis.Orphanet journal of rare diseases · 2020Pooled it
- Direct crosstalk between adult human retinas as suggested by interocular transfer of neurovascular coupling through photic stimulation.Scientific reports · 2025Article
- Pattern ERGs suggest a possible retinal contribution to the visual acuity loss in acute optic neuritis.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Sex-Specific Retinal Anomalies Induced by Chronic Social Defeat Stress in Mice.Frontiers in behavioral neuroscience · 2021Article
- Schizophrenia and the retina: Towards a 2020 perspective.Schizophrenia research · 2020Article
- V1 microcircuit dynamics: altered signal propagation suggests intracortical origins for adaptation in response to visual repetition.Journal of neurophysiology · 2019Article
- Reviewing the Role of the Efferent Vestibular System in Motor and Vestibular Circuits.Frontiers in physiology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe existence of retinopetal (sometimes referred to as "efferent" or "centrifugal") axons in the mammalian optic nerve is a topic of long-standing debate. Opposition is fading as efferent innervation of the retina has now been widely documented in rodents and other animals. The existence and function of an efferent system in humans and non-human primates has not, though, been definitively established. Such a feedback pathway could have important functional, clinical, and experimental significance to the field of vision science and ophthalmology.
methodsFollowing a comprehensive literature review (PubMed and Google Scholar, until July 2016), we present evidence regarding a system that can influence the bioelectrical activity of the retina in primates.
resultsAnatomical and physiological evidences are presented separately. Improvements in histological staining and the advent of retrograde nerve fiber tracers have allowed for more confidence in the identification of efferent optic nerve fibers, including back to their point of origin.
conclusionEven with the accumulation of more modern anatomical and physiological evidence, some limitations and uncertainties about crucial details regarding the origins and role of a top-down, efferent system still exist. However, the summary of the evidence from earlier and more modern studies makes a compelling case in support of such a system in humans and non-human primates.
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Registered trials
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