Evidence map›Paper›PMID 28032000›Full record

ArticleBrain and behavior2016

Reduced brain activation during inhibitory control in children with

Lora M Cope, Jillian E Hardee, Mary E Soules, Margit Burmeister, Robert A Zucker, Mary M Heitzeg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Brain Glucose Metabolism andDiagnostics (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lora M CopeDepartment of Psychiatry University of Michigan Ann Arbor MI USA; Addiction Center University of Michigan Ann Arbor MI USA.
Jillian E HardeeDepartment of Psychiatry University of Michigan Ann Arbor MI USA; Addiction Center University of Michigan Ann Arbor MI USA.
Mary E SoulesDepartment of Psychiatry University of Michigan Ann Arbor MI USA; Addiction Center University of Michigan Ann Arbor MI USA.
Margit BurmeisterDepartment of Psychiatry University of Michigan Ann Arbor MI USA; Molecular & Behavioral Neuroscience Institute University of Michigan Ann Arbor MI USA; Department of Human Genetics University of Michigan Ann Arbor MI USA.
Robert A ZuckerDepartment of Psychiatry University of Michigan Ann Arbor MI USA; Addiction Center University of Michigan Ann Arbor MI USA.
Mary M HeitzegDepartment of Psychiatry University of Michigan Ann Arbor MI USA; Addiction Center University of Michigan Ann Arbor MI USA.
University of Michigan–Ann Arbor · USMichigan Medicine · US

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
MULTIDISCIPLINARY ALCOHOLISM RESEARCH TRAINING PROGRAMT32AA007477 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maureen A. Walton · 1990 to 2026
$7.4M
Neurocognitive Risk For Alcoholism Into AdulthoodR01AA012217 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEITZEG, MARY M, ZUCKER, ROBERT ALPERT · 2000 to 2015
$7.3M
POSTDOCTORAL TRAINING IN THE BIOLOGY OF DRUG ABUSET32DA007268 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 1991 to 2021
$6.7M
RISK AND COPING IN CHILDREN OF ALCOHOLICSR01AA007065 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEITZEG, MARY M · 1987 to 2017
$6.1M
SUBSTANCE ABUSE INTERDISCIPLINARY TRAINING PROGRAMT32DA007267 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GNEGY, MARGARET E · 1994 to 2015
$4.5M
Brain Endophenotypes Modulating Drug Abuse RiskR01DA027261 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZUCKER, ROBERT ALPERT · 2009 to 2013
$3.3M
Longitudinal fMRI Study of Youth at Risk for Drug AbuseK01DA020088 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEITZEG, MARY M · 2005 to 2009
$732k
NCATS NIH HHS UL1 TR000433NIAAA NIH HHS R01 AA007065NIAAA NIH HHS R01 AA012217NIAAA NIH HHS T32 AA007477NIDA NIH HHS K01 DA020088NIDA NIH HHS R01 DA027261NIDA NIH HHS T32 DA007267NIDA NIH HHS T32 DA007268
6 · The paper itself

Abstract

introductionBehavioral undercontrol is a well-established risk factor for substance use disorder, identifiable at an early age well before the onset of substance use. However, the biological mechanistic structure underlying the behavioral undercontrol/substance use relationship is not well understood. The enzyme catechol

methodsParticipants were 65 (22 female) 7-12 year olds who were genotyped for the functional

resultsThere was a significant main effect of genotype on brain activation in left and right putamen during successful versus failed inhibition and in right inferior frontal gyrus/insula during successful inhibition versus baseline. Follow-up tests revealed that Met homozygotes had greater activation in each region relative to Val homozygotes.

conclusionsThese results are relevant for understanding how specific genes influence brain functioning related to underlying risk factors for substance use disorders and other disinhibitory psychopathologies.

Indexed as

Inhibition, PsychologicalBrainCatechol O-MethyltransferaseChildFemaleHumansMagnetic Resonance ImagingMalePolymorphism, Single NucleotideTask Performance and AnalysisValineCatechol O-MethyltransferaseCOMT protein, humanValinecatechol O‐methyltransferasechildrendopaminefunctional magnetic resonance imaginggo/no‐goinferior frontal gyrusinsulaputamenresponse inhibitionsubstance use disorder risk

Identifiers

PMID28032000
PMCPMC5167006
OpenAlexW2531867871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.