Evidence map›Paper›PMID 28031994›Full record

ArticleBrain and behavior2016

Covariation between plasma phosphate and daytime cortisol in early Parkinson's disease.

Lena Håglin, Lennart Bäckman

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lena HåglinDepartment of Public Health and Clinical Medicine, Family Medicine Umeå University Umeå Sweden.
Lennart BäckmanDepartment of Public Health and Clinical Medicine, Family Medicine Umeå University Umeå Sweden.
Umeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisturbed phosphate homeostasis in early Parkinson's disease (PD) may originate from a stress-related condition and nutritional status among other risk factors, age, and gender.

methodsRisk of malnutrition using Mini-nutritional assessment (MNA score) and plasma levels of protein markers and daytime cortisol at the time of diagnosis in PD (

resultsThe patients with PD had significantly lower MNA score than controls which correlated with plasma phosphate levels. The logistic regression revealed that increasing MNA protected from low plasma phosphate, final score (OR = 0.399; 95% CI = 0.196-0.816;

conclusionThis study highlights the importance of phosphate for optimal nutritional status by association with MNA score and albumin in plasma. An inverse relationship between phosphate and cortisol indicate, in addition, that low phosphate levels may affect cognition and motor function in PD.

Indexed as

AgedAged, 80 and overAntiparkinson AgentsCase-Control StudiesCircadian RhythmCognitionFemaleHumansHydrocortisoneLevodopaLogistic ModelsMaleMalnutritionMiddle AgedNutrition AssessmentParkinson DiseaseAntiparkinson AgentsHydrocortisoneLevodopaPhosphatesSerum AlbuminTransferrinalbumincognitioncortisolMini‐Nutritional AssessmentParkinson's diseasephosphatestresstransferrin

Identifiers

PMID28031994
PMCPMC5166997
OpenAlexW2527883211

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.