Evidence map›Paper›PMID 28031918›Full record

ArticleFuture science OA2015

New synthesis and biodistribution of the D-amino acid oxidase-magnetic nanoparticle system.

Francesca Cappellini, Camilla Recordati, Marcella De Maglie, Loredano Pollegioni, Federica Rossi, Marco Daturi, Rosalba Gornati, Giovanni Bernardini

Abstract read
In one paragraph

Article in Future science OA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesca CappelliniDipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy; Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy.
Camilla RecordatiMouse & Animal Pathology Laboratory, Fondazione Filarete, Viale Ortles, Milano, Italy; Mouse & Animal Pathology Laboratory, Fondazione Filarete, Viale Ortles, Milano, Italy.
Marcella De MaglieMouse & Animal Pathology Laboratory, Fondazione Filarete, Viale Ortles, Milano, Italy; Dipartimento di Scienze Veterinarie e Sanità Pubblica, Università degli Studi di Milano, Via Celoria, Milano, Italy; Mouse & Animal Pathology Laboratory, Fondazione Filarete, Viale Ortles, Milano, Italy; Dipartimento di Scienze Veterinarie e Sanità Pubblica, Università degli Studi di Milano, Via Celoria, Milano, Italy.
Loredano PollegioniDipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy; The Protein Factory, Politecnico di Milano and Università degli Studi dell'Insubria, Via Mancinelli 7, Milano, Italy; Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy; The Protein Factory, Politecnico di Milano and Università degli Studi dell'Insubria, Via Mancinelli 7, Milano, Italy.
Federica RossiDipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy; Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy.
Marco DaturiLaboratoire Catalyse et Spectrochimie, ENSICAEN, Universit' de Caen, CNRS, 6 Bd Maréchal Juin, F-14050 Caen, France; Laboratoire Catalyse et Spectrochimie, ENSICAEN, Universit' de Caen, CNRS, 6 Bd Maréchal Juin, F-14050 Caen, France.
Rosalba GornatiDipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy; The Protein Factory, Politecnico di Milano and Università degli Studi dell'Insubria, Via Mancinelli 7, Milano, Italy; Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy; The Protein Factory, Politecnico di Milano and Università degli Studi dell'Insubria, Via Mancinelli 7, Milano, Italy.
Giovanni BernardiniDipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy; The Protein Factory, Politecnico di Milano and Università degli Studi dell'Insubria, Via Mancinelli 7, Milano, Italy; Dipartimento di Biotecnologie e Scienze della Vita, Università degli Studi dell'Insubria, Via Dunant 3, Varese, Italy; The Protein Factory, Politecnico di Milano and Università degli Studi dell'Insubria, Via Mancinelli 7, Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApplication of nanoenzymes, based on D-amino acid oxidase (DAAO) conjugated to magnetic nanoparticles (NPs), as anticancer system requires improvement of the synthesis protocol and

resultsA new and more efficient synthesis via EDC-NHS produced an Fe

conclusionsOur results support the possibility to use enzymes conjugated to magnetic NPs for cancer treatment. Besides, we think that enzymes and other biological molecules efficiently conjugated to magnetic NPs might constitute a category of 'bionanoparticles' to be exploited, not only in medical, but also in industrial biotechnology.

Indexed as

anticancer systembionanoparticlesin vivo analysisironIR spectroscopynanoenzymenanoparticles

Identifiers

PMID28031918
PMCPMC5138019

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.