Evidence map›Paper›PMID 28031897›Full record

ArticleFuture science OA2015

Portable nanoporous electrical biosensor for ultrasensitive detection of Troponin-T.

Nandhinee Radha Shanmugam, Anjan Panneer Selvam, Thomas W Barrett, Steven C Kazmierczak, Milin Nilesh Rana, Shalini Prasad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. A Cardiac Troponin T Biosensor Based on Aptamer Self-assembling on Gold.International journal of molecular and cellular medicine · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nandhinee Radha ShanmugamDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA; Department of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.
Anjan Panneer SelvamDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA; Department of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.
Thomas W BarrettDepartment of Veterans Affairs, Oregon Health & Science University, Portland, OR, USA; Department of Veterans Affairs, Oregon Health & Science University, Portland, OR, USA.
Steven C KazmierczakDepartment of Pathology, Oregon Health & Science University, Portland, OR, USA; Department of Pathology, Oregon Health & Science University, Portland, OR, USA.
Milin Nilesh RanaDepartment of Molecular & Cell Biology, University of Texas at Dallas, Richardson, TX, USA; Department of Molecular & Cell Biology, University of Texas at Dallas, Richardson, TX, USA.
Shalini PrasadDepartment of Bioengineering, University of Texas at Dallas, Richardson, TX, USA; Department of Bioengineering, University of Texas at Dallas, Richardson, TX, USA.
The University of Texas at Dallas · USOregon Health & Science University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo demonstrate the design, fabrication and testing of a portable, label-free biosensor for ultrasensitive detection of the cardiac Troponin-T (cTnT) from patient blood. MATERIALS &

methodsThe biosensor is comprised of a nanoporous membrane integrated on to a microelectrode sensor platform for nanoconfinement effects. Charge perturbations due to antigen binding are recorded as impedance changes using electrochemical impedance spectroscopy.

resultsThe measured impedance change is used to quantitatively determine the cTnT concentration from the tested sample. We were successful in detecting and quantifying cardiac Troponin-T from a 40-patient cohort. The limit of detection was 0.01 pg/ml.

conclusionThis novel technology has promising preliminary results for rapid and sensitive detection of cTnT.

Indexed as

electrical double layerimpedance spectroscopynanoconfinementnanoporousTroponin-T

Identifiers

PMID28031897
PMCPMC5137999
OpenAlexW1636310617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.