Evidence map›Paper›PMID 28031891›Full record

ArticleFuture science OA2015

Invertible micellar polymer nanoassemblies target bone tumor cells but not normal osteoblast cells.

Olena Kudina, Kristen L Shogren, Carl T Gustafson, Michael J Yaszemski, Avudaiappan Maran, Andriy Voronov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Olena KudinaDepartment of Coatings & Polymeric Materials, North Dakota State University, Fargo, ND 58105-6050, USA (currently Department of Science & Technology University of Twente, the Netherlands); Department of Coatings & Polymeric Materials, North Dakota State University, Fargo, ND 58105-6050, USA (currently Department of Science & Technology University of Twente, the Netherlands).
Kristen L ShogrenDepartment of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA; Department of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA.
Carl T GustafsonDepartment of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA; Department of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA.
Michael J YaszemskiDepartment of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA; Department of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA.
Avudaiappan MaranDepartment of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA; Department of Orthopedics, Mayo Clinic, Rochester, MN 55905, USA.
Andriy VoronovDepartment of Coatings & Polymeric Materials, North Dakota State University, Fargo, ND 58105-6050, USA; Department of Coatings & Polymeric Materials, North Dakota State University, Fargo, ND 58105-6050, USA.
Mayo Clinic in Arizona · USMayo Clinic · USNorth Dakota State University · USUniversity of Twente · NL

Funding

Predoctoral Training Program in Molecular PharmacologyT32GM072474 · NIGMS · MAYO CLINIC ROCHESTER · PI KARNITZ, LARRY M · 2005 to 2020
$2.4M
NIGMS NIH HHS T32 GM072474
6 · The paper itself

Abstract

aimTo demonstrate the capability of the invertible micellar polymer nanoassemblies (IMAs) to deliver and release curcumin using the recently discovered mechanism of macromolecular inversion to treat bone tumor cells. MATERIALS &

methodsThe effect of IMA-mediated delivery of curcumin on osteosarcoma cell survival was investigated using MTS assays. To assess the effect of IMAs-delivered curcumin on osteosarcoma cell growth, fluorescence-activated cell sorting was performed. The uptake of micellar nanoassemblies was followed using confocal microscopy. RESULTS & DISCUSSION: IMAs-delivered curcumin is effective in blocking osteosarcoma cell growth. It decreases cell viability in human osteosarcoma (MG63, KHOS, and LM7) cells while having no effect on normal human osteoblast cells. It indicates that curcumin-loaded IMAs provide a unique delivery system targeted to osteosarcoma cells.

Indexed as

bone tumor treatmentcurcumin deliveryinvertible polymer micellesmicellar nanoassemblies

Identifiers

PMID28031891
PMCPMC5137969
OpenAlexW2180485882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.