Evidence map›Paper›PMID 28031877›Full record

ArticleFuture science OA2015

Injectable liposomal formulations of opiorphin as a new therapeutic strategy in pain management.

Natascia Mennini, Paola Mura, Cristina Nativi, Barbara Richichi, Lorenzo Di Cesare Mannelli, Carla Ghelardini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. A Novel Ophthalmic Solution Containing GlicoproJournal of clinical medicine · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natascia MenniniDepartment of Chemistry, University of Florence, Polo Scientifico Sesto Fiorentino, Sesto Fiorentino (FI), Italy; Department of Chemistry, University of Florence, Polo Scientifico Sesto Fiorentino, Sesto Fiorentino (FI), Italy.
Paola MuraDepartment of Chemistry, University of Florence, Polo Scientifico Sesto Fiorentino, Sesto Fiorentino (FI), Italy; Department of Chemistry, University of Florence, Polo Scientifico Sesto Fiorentino, Sesto Fiorentino (FI), Italy.
Cristina NativiDepartment of Chemistry, University of Florence, Polo Scientifico Sesto Fiorentino, Sesto Fiorentino (FI), Italy; Department of Chemistry, University of Florence, Polo Scientifico Sesto Fiorentino, Sesto Fiorentino (FI), Italy.
Barbara RichichiDepartment of Chemistry, University of Florence, Polo Scientifico Sesto Fiorentino, Sesto Fiorentino (FI), Italy; Department of Chemistry, University of Florence, Polo Scientifico Sesto Fiorentino, Sesto Fiorentino (FI), Italy.
Lorenzo Di Cesare MannelliDepartment of Neurosciences, Psychology, Drug Research & Child Health, University of Florence, Firenze, Italy; Department of Neurosciences, Psychology, Drug Research & Child Health, University of Florence, Firenze, Italy.
Carla GhelardiniDepartment of Neurosciences, Psychology, Drug Research & Child Health, University of Florence, Firenze, Italy; Department of Neurosciences, Psychology, Drug Research & Child Health, University of Florence, Firenze, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConventional and PEGylated liposomes were developed, aimed at improving the pain-killing effect of opiorphin.

methodsThe antinociceptive action of the formulations was investigated on rats (tail-flick test), and compared with that of opiorphin and morphine aqueous solutions (all at 5 mg/kg).

resultsOpiorphin loading in conventional liposomes enabled a 28% AUC increase with respect to free peptide. PEGylated liposomes provided AUC values 80, 60 and 40% higher than free peptide, morphine and opiorphin-loaded conventional liposomes, respectively. Moreover, opiorphin entrapment in PEGylated liposomes increased analgesic effect duration by more than 50%. These results were attributed to the greater effectiveness of PEGylated liposomes in protecting the drug and prolonging its circulation time.

conclusionOpiorphin-loaded PEGylated-liposomes can represent a valid alternative to morphine in pain management.

Indexed as

conventional liposomesimproved antinociceptionopiorphinPEGylated liposomestail-flick latency test

Identifiers

PMID28031877
PMCPMC5137926

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.