Evidence map›Paper›PMID 28031861›Full record

ReviewFuture science OA2015

Nitric oxide therapy for dermatologic disease.

Brandon L Adler, Adam J Friedman

Open access · goldAbstract readReview
In one paragraph

Review in Future science OA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Brandon L AdlerDepartment of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA.
Adam J FriedmanDepartment of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA; Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA; George Washington School of Medicine & Health Sciences, Washington, DC, USA; Department of Medicine (Division of Dermatology), Albert Einstein College of Medicine, Bronx, NY, USA; Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA; George Washington School of Medicine & Health Sciences, Washington, DC, USA.
Albert Einstein College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitric oxide (NO) plays an important role in the maintenance and regulation of the skin and the integrity of its environment. Derangement of NO production is implicated in the etiology of a multitude of dermatologic diseases, indicating future therapeutic directions. In an era of increasing resistance rates to available antibiotics and subpar development of new agents, NO is promising as a prospective topical broad-spectrum antimicrobial agent with small likelihood of resistance development. Because the greatest strides have been made in the setting of infectious disease and skin and soft-tissue infection, this will be a major focus of this article. In addition, we will review NO's role in skin regulation and dysregulation, immune function, the various topical release systems that have been devised and tested, NO's relation to UV radiation and skin pigmentation, and finally, its potential applications as a cosmeceutical.

Indexed as

cosmeceuticalnitric oxide synthaseNOSreactive nitrogen oxide speciesRNOSskin and soft-tissue infectionSSTI

Identifiers

PMID28031861
PMCPMC5137922
OpenAlexW2183838214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.