ReviewAdolescent health, medicine and therapeutics2017
Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges.
Review in Adolescent health, medicine and therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Paraneoplastic Syndromes in Gallbladder Cancer: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- The efficacy of topical treatments for acanthosis nigricans: a systematic review of randomized controlled trials.Frontiers in medicine · 2025Pooled it
- Gender, racial, ethnic, and Fitzpatrick skin type representation in Acanthosis nigricans clinical trials.Archives of dermatological research · 2024Pooled it
- New Perspectives on Nutraceutical Insulin Sensitizing Agents in the Treatment of Psoriasis and Other Dermatological Diseases.International journal of molecular sciences · 2025Review
- Article
- Acanthosis nigricans - a potentially useful clue to the presence of significant occult disease at autopsy.Forensic science, medicine, and pathology · 2025Article
- Manifestations and etiology of cutaneous findings in cases of morbid obesity.Forensic science, medicine, and pathology · 2024Review
- Prediabetes in children and adolescents: An updated review.World journal of clinical pediatrics · 2023Review
- Fractional Carbon Dioxide Laser versus Trichloroacetic Acid 20% Peel in the Treatment of Acanthosis Nigricans: A Split Neck Comparative Study.The Journal of clinical and aesthetic dermatology · 2023Article
- Improved Insulin Secretion Response and Beta-cell Function Correlated with Increased Prolactin Levels After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients with Acanthosis Nigricans.Obesity surgery · 2023Article
- Acanthosis nigricans in the pediatric population: a narrative review of the current approach to management in primary care.Pediatric medicine (Hong Kong, China) · 2022Article
- Prevalence of acanthosis nigricans and its association with physical activity in adolescents - School-based analytical cross-sectional study from Kochi, Kerala.Journal of family medicine and primary care · 2021Article
- Skin anomalies in acromegalic patients (Review of the practical aspects).Experimental and therapeutic medicine · 2021Review
- Acanthosis Nigricans in Children and Adolescents with Type 1 Diabetes or Obesity: The Potential Interplay Role between Insulin Resistance and Excess Weight.Children (Basel, Switzerland) · 2021Article
- Malignant acanthosis nigricans with Leser-Trélat sign and tripe palms: A case report.World journal of clinical cases · 2020Article
- Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents.Annals of pediatric endocrinology & metabolism · 2019Article
- A follow-up during puberty in a Japanese girl with type A insulin resistance due to a novel mutation inClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2018Article
- Laparoscopic sleeve gastrectomy improves body composition and alleviates insulin resistance in obesity related acanthosis nigricans.Lipids in health and disease · 2017Article
- Chronic Inflammatory Markers in Overweight and Obese Children: A Cross-sectional Analytical Study.Indian journal of endocrinology and metabolismArticle
- Effectiveness and Safety of Metformin versus Canthex™ in Patients with Acanthosis Nigricans: A Randomized, Double-blind Controlled Trial.Indian journal of dermatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity in adolescence is a public health priority because it usually tracks into adulthood, resulting in enormous medical and social costs. This underscores the importance of early identification and intervention. Acanthosis nigricans (AN) was once considered a rare paraneoplastic dermatosis, but is now frequently observed in obese adolescents. Current understanding suggests that it is associated with insulin resistance and has a unique role in secondary prevention. The purpose of this narrative review is to provide a comprehensive overview of AN in obese adolescents, covering its history, current knowledge on the condition, its clinical significance, management challenges, and the direction of future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.