ArticleOncoTargets and therapy2017
Atypical aleukemic presentation of large granular lymphocytic leukemia: a case report.
Article in OncoTargets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A Rare Case of T-Large Granular Lymphocytic (T-LGL) Leukemia in a Patient With Rheumatoid Arthritis With Neutropenia and Low LGL Level.Case reports in oncological medicine · 2025Article
- Isolated anemia in patients with large granular lymphocytic leukemia (LGLL).Blood cancer journal · 2022Article
- Cell-type-specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells.International journal of clinical oncology · 2019Article
- STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia.Journal for immunotherapy of cancer · 2019Observational
- DNA demethylation marks in chronic lymphocytic leukemia: it is time to let the cat out of the bag.Future science OA · 2018Article
- Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab.Case reports in hematology · 2017Article
- T-Cell Large Granular Lymphocyte Leukemia in a Patient With Rheumatoid Arthritis.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
6 authors.
Funding
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Abstract
Large granular lymphocytic leukemia (LGLL) is a rare lymphoproliferative disorder of transformed natural killer or T-cells attributed to chronic exposure to the proinflammatory cytokine IL-15. Diagnosis of the majority of T-cell LGLL is established by documenting clonal large granular lymphocytes (LGLs) in peripheral blood, by morphology and immunophenotype. The proteasome inhibitor bortezomib is known to target molecular pathways downstream of the IL-15 receptor signaling and has been proposed as a therapy in these patients. We report an uncommon presentation of LGLL with chronic neutropenia lacking typical blood LGLs, which failed to respond to bortezomib but obtained a very good partial remission with a classical methotrexate regimen.
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