ArticleClinical ophthalmology (Auckland, N.Z.)2017
Clinical and histological evaluation of large macular hole surgery using the inverted internal limiting membrane flap technique.
Article in Clinical ophthalmology (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04904679 (The Use of Amniotic Membrane or Inverted Internal Limiting Membrane Flap for Large or Refractory Macular Holes), which is not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Amniotic Membrane or Inverted Internal Limiting Membrane Flap for Large or Refractory Macular Holes: a Prospective, Comparative Study Using Microperimetry
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Efficacy of inverted inner limiting membrane flap technique for macular holes of ≤400 μm: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Comparative efficacy evaluation of inverted internal limiting membrane flap technique and internal limiting membrane peeling in large macular holes: a systematic review and meta-analysis.BMC ophthalmology · 2020Pooled it
- Pooled it
- Inverted internal limiting membrane flap technique for large macular holes: a systematic review and single-arm meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Pooled it
- The use of amniotic membrane or inverted internal limiting membrane flap for large or refractory macular holes: a prospective, comparative study using microperimetry.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Trial
- Multilayered inverted internal limiting membrane flap technique versus standard internal limiting membrane peeling for large macular holes: A comparative study.Indian journal of ophthalmology · 2022Trial
- A discrepancy in epiretinal proliferation detection between preoperative OCT and intraoperative observation in macular hole.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Retinal displacement after surgery for idiopathic macular hole.International journal of ophthalmology · 2024Review
- Epiretinal proliferation embedding combined with internal limiting membrane flap inversion for secondary macular hole: Two case reports.American journal of ophthalmology case reports · 2023Article
- Effect of inverted internal limiting membrane flap technique on small-medium size macular holes.Scientific reports · 2022Article
- Internal limiting membrane peeling in macular hole surgery.German medical science : GMS e-journal · 2022Review
- [Biomarkers in full-thickness and lamellar defects of the macula].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Review
- Autologous full-thickness retinal transplant for refractory large macular holes.International journal of retina and vitreous · 2020Article
- Microperimetric Biofeedback Training after Successful Inverted Flap Technique for Large Macular Hole.Journal of clinical medicine · 2020Article
- Internal limiting membrane insertion technique combined with nerve growth factor injection for large macular hole.BMC ophthalmology · 2019Article
- [Surgery of large and persistent macular holes].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Review
- Dynamic intraoperative optical coherence tomography for inverted internal limiting membrane flap technique in large macular hole surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Observational
- [Vitrectomy and iOCT-assisted inverted ILM flap technique in patients with full thickness macular holes].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Article
- Inverted internal limiting membrane-flap technique for large macular hole: a microperimetric study.International journal of retina and vitreous · 2019Article
- The Role of Single-Layered Flap in Temporal Inverted Internal Limiting Membrane Flap Technique for Macular Holes: Pros and Cons.Journal of ophthalmology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aims of this study were to analyze optical coherence tomography (OCT) imaging of large macular holes (MHs) treated with inverted internal limiting membrane (ILM) flap technique and to perform a histological examination of an ILM-like membrane tissue obtained during vitrectomy. PATIENTS AND
methodsThis is a retrospective observational case study. Nine patients, comprising of five males and four females, showing large and myopic MHs, underwent pars plana vitrectomy (PPV) with inverted ILM flap technique assisted by brilliant blue G (BBG) staining. Ophthalmological findings including visual acuity and OCT were investigated based on medical records. Formalin-fixed paraffin-embedded tissue section of an ILM-like membrane was submitted for immunohistochemistry with glial fibrillary acidic protein (GFAP).
resultsILM was clearly stained with BBG in eight patients, whereas the ILM in one case revealed no staining with BBG during PPV. Visual acuities improved to >0.2 LogMAR in six patients. The complete closure of MH following PPV with inverted ILM technique was eventually achieved in all patients determined by OCT imaging (100%). Only one patient showed recovery of ellipsoid zone and interdigitation zone following the surgery. Elongation of outer nuclear layer was noted in three eyes. The ILM-like membrane not stained with BBG histologically revealed an amorphous structure admixed with GFAP-positive mononuclear cell infiltration.
conclusionPPV with inverted ILM flap technique achieved 100% closure rates with favorable configuration at an initial surgery in large MHs. Our histopathological data also suggest that even BBG staining-negative membrane may be a useful material for autologous transplantation to the hole.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.