Evidence map›Paper›PMID 28031524›Full record

ArticleOncotarget2017

Adenosine 5'-monophosphate blocks acetaminophen toxicity by increasing ubiquitination-mediated ASK1 degradation.

Xiao Yang, Yibei Zhan, Qi Sun, Xi Xu, Yi Kong, Jianfa Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiao YangCenter for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing, 210094, China.
Yibei ZhanCenter for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing, 210094, China.
Qi SunCenter for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing, 210094, China.
Xi XuCenter for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing, 210094, China.
Yi KongSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Jianfa ZhangCenter for Molecular Metabolism, Nanjing University of Science and Technology, Nanjing, 210094, China.
Nanjing University of Science and Technology · CNChina Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure in the world. Hepatic c-jun NH2-terminal protein kinase (JNK) activation is thought to be a consequence of oxidative stress produced during APAP metabolism. Activation of JNK signals causes hepatocellular damage with necrotic and apoptotic cell death. Here we found that APAP caused a feedback increase in plasma adenosine 5'-monophsphate (5'-AMP). We demonstrated that co-administration of APAP and 5'-AMP significantly ameliorated APAP-induced hepatotoxicity in mice, without influences on APAP metabolism and its analgesic function. The mechanism of protection by 5'-AMP was through inhibiting APAP-induced activation of JNK, and attenuating downstream c-jun and c-fos gene expression. This was triggered by attenuating apoptosis signal-regulated kinase 1(ASK1) methylation and increasing ubiquitination-mediated ASK1 protein degradation. Our findings indicate that replacing the current APAP with a safe and functional APAP/5'-AMP formulation could prevent APAP-induced hepatotoxicity.

Indexed as

AcetaminophenAdenosine MonophosphateAnimalsChemical and Drug Induced Liver InjuryCytoprotectionDisease Models, AnimalDose-Response Relationship, DrugEnzyme ActivationJNK Mitogen-Activated Protein KinasesLiverMaleMAP Kinase Kinase Kinase 5MethylationMice, Inbred C57BLProtective AgentsProteolysisAcetaminophenAdenosine MonophosphateJNK Mitogen-Activated Protein KinasesMap3k5 protein, mouseMAP Kinase Kinase Kinase 5Protective AgentsProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-jun5′-AMPAPAPASK1hepatotoxicityJNK

Identifiers

PMID28031524
PMCPMC5351630
OpenAlexW2566220566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.