ArticleJournal of neurophysiology2017
Spinal cord direct current stimulation differentially modulates neuronal activity in the dorsal and ventral spinal cord.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Spinal direct current stimulation (tsDCS) in hereditary spastic paraplegias (HSP): A sham-controlled crossover study.The journal of spinal cord medicine · 2021Trial
- Cervical Spinal Cord Stimulation for Functional Rehabilitation After Spinal Cord Injury: A Systematic Review of Preclinical and Clinical Studies.Life (Basel, Switzerland) · 2026Review
- Human spinal cord activation during filling and emptying of the bladder.Nature communications · 2025Article
- Direct current stimulation as a non-invasive therapeutic alternative for treating autonomic or non-autonomic neurological disorders affecting breathing.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- The Dopaminergic System Modulates the Electrophysiological Activity of the Suprachiasmatic Nucleus Dependent on the Circadian Cycle.Neurochemical research · 2023Article
- Boosting corticospinal system synaptic plasticity to recover motor functions.Neural regeneration research · 2023Article
- Article
- Unraveling age-related impairment of the neuromuscular system: exploring biomechanical and neurophysiological perspectives.Frontiers in physiology · 2023Review
- The effect of cathodal transspinal direct current stimulation on tibialis anterior stretch reflex components in humans.Experimental brain research · 2022Article
- Trans-Spinal Direct Current Stimulation Targets CaFrontiers in neuroscience · 2022Article
- Spinal cord representation of motor cortex plasticity reflects corticospinal tract LTP.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Article
- Transcutaneous spinal direct current stimulation increases corticospinal transmission and enhances voluntary motor output in humans.Physiological reports · 2020Article
- Intrinsic functional architecture of the non-human primate spinal cord derived from fMRI and electrophysiology.Nature communications · 2019Article
- Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays.The Journal of physiology · 2019Article
- Transneuronal Downregulation of the Premotor Cholinergic System After Corticospinal Tract Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Motor cortex and spinal cord neuromodulation promote corticospinal tract axonal outgrowth and motor recovery after cervical contusion spinal cord injury.Experimental neurology · 2017Article
- Spinal control of motor outputs by intrinsic and externally induced electric field potentials.Journal of neurophysiology · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Spinal cord direct current stimulation (sDCS) has the potential for promoting motor function after injury through its modulatory actions on sensory processing, reflex functions, the motor cortex (M1) motor map, and motor output. Here we addressed systems-level mechanisms underlying sDCS neuromodulation of spinal circuits activated by M1 and peripheral forelimb electrical stimulation in anesthetized healthy rats. We determined the effects of cathodal and anodal sDCS (c- and a-sDCS) on local field potentials (LFP) and single-unit activity recorded at 32 sites simultaneously within the sixth cervical segment using a silicon multielectrode array. M1 stimulation produced distinctive dorsomedial and ventral LFP responses that showed polarity-dependent sDCS modulation. c-sDCS enhanced and a-sDCS depressed significantly ventral M1 responses; neither modulated dorsal responses significantly. Using evoked changes in β- and γ-oscillations to assay network function, c-sDCS enhanced and a-sDCS reduced oscillation power ventrally. c-sDCS increased and a-sDCS decreased background firing and firing synchrony of recorded pairs of single units. Peripheral stimulation produced a region-dependent response that showed polarity-dependent sDCS modulation. The dorsomedial LFP was unaffected by c-sDCS and weakly suppressed with a-sDCS. Peripheral-evoked unit responses showed limited polarity dependence. Our findings stress that ventral motor network behavior is enhanced by the neuromodulatory actions of c-sDCS. The combined actions of c-sDCS on M1-evoked neural responses and network behavior in the cervical spinal cord help explain the reported enhanced motor effects of this neuromodulation approach and inform the mechanisms of sDCS for promoting motor rehabilitation after spinal cord or brain injury.
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