Evidence map›Paper›PMID 28031340›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

IL-15 Enables Septic Shock by Maintaining NK Cell Integrity and Function.

Yin Guo, Liming Luan, Naeem K Patil, Jingbin Wang, Julia K Bohannon, Whitney Rabacal, Benjamin A Fensterheim, Antonio Hernandez, Edward R Sherwood

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Review
  3. Impaired peripheral mononuclear cell metabolism in patients at risk of developing sepsis: A cohort study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026
    Article
  4. Article
  5. Article
  6. Targeting sepsis through inflammation and oxidative metabolism.World journal of critical care medicine · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. NK Cell-Derived IL-10 Supports Host Survival during Sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yin GuoDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212; and.
Liming LuanDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232.
Naeem K PatilDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232.
Jingbin WangDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232.
Julia K BohannonDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232.
Whitney RabacalDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212; and.
Benjamin A FensterheimDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212; and.
Antonio HernandezDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232.ORCID 0000-0003-1651-9037
Edward R SherwoodDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37212; and edward.r.sherwood@vanderbilt.edu.
Vanderbilt University Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Training Innate Immunity: A new approach to the treatment of SepsisR01GM119197 · NIGMS · EAST TENNESSEE STATE UNIVERSITY · PI SHERWOOD, EDWARD R, WILLIAMS, DAVID L. · 2016 to 2024
$4.6M
Resistance of Beta 2 Microglobulin Null Mice to SepsisR01GM066885 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHERWOOD, EDWARD R · 2003 to 2016
$4.4M
Augmentation of Innate Anti-Microbial Immunity by TLR4 AgonistsR01GM104306 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENKHBAATAR, PERENLEI, SHERWOOD, EDWARD R · 2013 to 2016
$1.2M
NIGMS NIH HHS R01 GM066885NIGMS NIH HHS R01 GM104306NIGMS NIH HHS R01 GM119197NIGMS NIH HHS T32 GM007347
6 · The paper itself

Abstract

Interleukin 15 is essential for the development and differentiation of NK and memory CD8

Indexed as

AnimalsFemaleInterferon-gammaInterleukin-15Killer Cells, NaturalMaleMiceMice, Inbred C57BLMice, KnockoutShock, SepticInterferon-gammaInterleukin-15

Identifiers

PMID28031340
PMCPMC5263185
OpenAlexW2561430138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.