Evidence map›Paper›PMID 28031265›Full record

ArticleInfection and immunity2017

The Carbohydrate Lectin Receptor Dectin-1 Mediates the Immune Response to Exserohilum rostratum.

Jennifer L Reedy, Paige E Negoro, Marianela Feliu, Allison K Lord, Nida S Khan, Dan P Lukason, Nathan P Wiederhold, Jenny M Tam, Michael K Mansour, Thomas F Patterson and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. It takes a village: Phagocytes play a central role in fungal immunity.Seminars in cell & developmental biology · 2019
    Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jennifer L ReedyDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Paige E NegoroDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Marianela FeliuDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Allison K LordDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nida S KhanDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Dan P LukasonDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nathan P WiederholdThe University of Texas Health Science Center at San Antonio and South Texas Veterans Health Care System, San Antonio, Texas, USA.
Jenny M TamDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Michael K MansourDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Thomas F PattersonThe University of Texas Health Science Center at San Antonio and South Texas Veterans Health Care System, San Antonio, Texas, USA.
Jatin M VyasDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA jvyas@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-9985-9565
Massachusetts General Hospital · USHarvard University · USThe University of Texas Health Science Center at San Antonio · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Functional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive ImmunityR01AI092084 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2011 to 2015
$2.2M
The role of TLR9 on Aspergillus fumigatus phagosomesR01AI097519 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2013 to 2016
$1.6M
Subcellular Mechanisms for Fungal Phagosome Maturation in MacrophagesK08AI110655 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MANSOUR, MICHAEL K · 2014 to 2017
$759k
Systems Analysis of Innate Immune Responses to Fungal-Derived CarbohydratesR21AI109303 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2015 to 2016
$479k
NCATS NIH HHS KL2 TR001100NIAID NIH HHS K08 AI110655NIAID NIH HHS R01 AI092084NIAID NIH HHS R21 AI109303NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

Dematiaceous molds are found ubiquitously in the environment and cause a wide spectrum of human disease, including infections associated with high rates of mortality. Despite this, the mechanism of the innate immune response has been less well studied, although it is key in the clearance of fungal pathogens. Here, we focus on

Indexed as

Adrenal Cortex HormonesAntifungal AgentsAscomycotaCarbohydratesCell WallCytokinesDectin-1Host-Pathogen InteractionsHumansHyphaeLectins, C-TypeMacrophagesMycosesPhagocytosisSpores, FungalTumor Necrosis Factor-alphaAdrenal Cortex HormonesAntifungal AgentsCarbohydratesCytokinesDectin-1Lectins, C-TypeTumor Necrosis Factor-alphaDectin-1Exserohilumfungimacrophagesmolds

Identifiers

PMID28031265
PMCPMC5328484
OpenAlexW2564783874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.