ArticleGenes & development2016
Thioredoxin-dependent disulfide bond reduction is required for protamine eviction from sperm chromatin.
Article in Genes & development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Impact of selenium and selenoproteins on idiopathic male infertility: a comprehensive review.Frontiers in nutrition · 2025Review
- TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth.EMBO reports · 2024Article
- Biophysical ordering transitions underlie genome 3D re-organization during cricket spermiogenesis.Nature communications · 2023Article
- Improvement of Fertilization Capacity and Developmental Ability of Vitrified Bovine Oocytes by JUNO mRNA Microinjection and Cholesterol-Loaded Methyl-β-Cyclodextrin Treatment.International journal of molecular sciences · 2022Article
- Exploring Structures and Dynamics of Protamine Molecules through Molecular Dynamics Simulations.ACS omega · 2022Article
- Sperm Redox System Equilibrium: Implications for Fertilization and Male Fertility.Advances in experimental medicine and biology · 2022Article
- Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain.PLoS genetics · 2022Article
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- The Lid/KDM5 histone demethylase complex activates a critical effector of the oocyte-to-zygote transition.PLoS genetics · 2020Article
- TheeLife · 2019Article
- Prolonged ovarian storage of matureeLife · 2019Article
- Redox Regulation and Oxidative Stress: The Particular Case of the Stallion Spermatozoa.Antioxidants (Basel, Switzerland) · 2019Review
- Cytochemical tests to investigate sperm DNA damage: Assessment and review.Journal of family medicine and primary care · 2019Review
- Activating embryonic development in Drosophila.Seminars in cell & developmental biology · 2018Review
- Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Evaluation of Sperm Chromatin Integrity Using Aniline Blue and Toluidine Blue Staining in Infertile and Normozoospermic Men.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cysteine oxidation in protamines leads to their oligomerization and contributes to sperm chromatin compaction. Here we identify the Drosophila thioredoxin Deadhead (DHD) as the factor responsible for the reduction of intermolecular disulfide bonds in protamines and their eviction from sperm during fertilization. Protamine chaperone TAP/p32 dissociates DNA-protamine complexes in vitro only when protamine oligomers are first converted to monomers by DHD. dhd-null embryos cannot decondense sperm chromatin and terminate development after the first pronuclear division. Therefore, the thioredoxin DHD plays a critical role in early development to facilitate the switch from protamine-based sperm chromatin structures to the somatic nucleosomal chromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.