Evidence map›Paper›PMID 28031238›Full record

ArticleCancer genomics & proteomics2017

Customized Array Comparative Genomic Hybridization Analysis of 25 Phosphatase-encoding Genes in Colorectal Cancer Tissues.

Izabela Laczmanska, Pawel Skiba, Pawel Karpinski, Marek Bebenek, Maria M Sasiadek

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer genomics & proteomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Izabela LaczmanskaGenetics Department, Wroclaw Medical University, Wroclaw, Poland iza.laczmanska@gmail.com.
Pawel SkibaGenetics Department, Wroclaw Medical University, Wroclaw, Poland.
Pawel KarpinskiGenetics Department, Wroclaw Medical University, Wroclaw, Poland.
Marek Bebenek1st Department of Surgical Oncology, Lower Silesian Oncology Center, Wroclaw, Poland.
Maria M SasiadekGenetics Department, Wroclaw Medical University, Wroclaw, Poland.
Wroclaw Medical University · PLLublin Oncology Center · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimMolecular mechanisms of alterations in protein tyrosine phosphatases (PTPs) genes in cancer have been previously described and include chromosomal aberrations, gene mutations, and epigenetic silencing. However, little is known about small intragenic gains and losses that may lead to either changes in expression or enzyme activity and even loss of protein function. MATERIALS AND

methodsThe aim of this study was to investigate 25 phosphatase genes using customized array comparative genomic hybridization in 16 sporadic colorectal cancer tissues.

resultsThe analysis revealed two unique small alterations: of 2 kb in PTPN14 intron 1 and of 1 kb in PTPRJ intron 1. We also found gains and losses of whole PTPs gene sequences covered by large chromosome aberrations.

conclusionIn our preliminary studies using high-resolution custom microarray we confirmed that PTPs are frequently subjected to whole-gene rearrangements in colorectal cancer, and we revealed that non-polymorphic intragenic changes are rare.

Indexed as

Comparative Genomic HybridizationAgedAged, 80 and overChromosome AberrationsChromosome MappingColorectal NeoplasmsEpigenesis, GeneticFemaleHumansMaleMiddle AgedMultigene FamilyPhosphoric Monoester HydrolasesProtein Tyrosine PhosphatasesProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)KRAS protein, humanPhosphoric Monoester HydrolasesProtein Tyrosine PhosphatasesProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)aCGHcolorectal cancerprotein tyrosine phosphatases

Identifiers

PMID28031238
PMCPMC5267501
OpenAlexW2567093895

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.