ArticleCancer genomics & proteomics2017
Expression Profiling of a Human Thyroid Cell Line Stably Expressing the BRAFV600E Mutation.
Article in Cancer genomics & proteomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Cell cycle and HIF-1 related gene expression alteration in thyroid cell lines under microgravity.Oncology research · 2025Article
- BRAFV600E Mutation Enhances Estrogen-Induced Metastatic Potential of Thyroid Cancer by Regulating the Expression of Estrogen Receptors.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Induction of the BRAFV600E Mutation in Thyroid Cells Leads to Frequent Hypermethylation.Clinical and experimental otorhinolaryngology · 2022Article
- Article
- Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- Methylation dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma.PloS one · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimThe BRAF MATERIALS AND
methodsTo study genomic alterations caused by the BRAF
resultsFlow cytometry and western blotting showed stable transfection of the BRAF gene. In functional experiments, Nthy/V600E showed increased anchorage-independent growth and invasion through Matrigel, compared to Nthy/WT. Microarray analysis revealed that 2,441 genes were up-regulated in Nthy/V600E compared to Nthy/WT. Gene ontology analysis showed that the up-regulated genes were associated with cell adhesion, migration, and the ERK and MAPK cascade, and pathway analysis showed enrichment in cancer-related pathways.
conclusionOur Nthy/WT and Nthy/V600E cell line pair could be a suitable model to study the molecular characteristics of BRAF
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Registered trials
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