ArticleEuropean heart journal. Cardiovascular Imaging2017
Quantitative intravascular biological fluorescence-ultrasound imaging of coronary and peripheral arteries in vivo.
Article in European heart journal. Cardiovascular Imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- High-Speed Intravascular Near-Infrared Fluorescence-Ultrasound Imaging In Vivo.IEEE transactions on bio-medical engineering · 2026Article
- Coronary Intravascular Imaging: A Comprehensive Review of Techniques, Applications, and Future Directions.Medicina (Kaunas, Lithuania) · 2025Review
- Optical theranostics in ischemic heart disease: from molecular insights to clinical translation.Theranostics · 2025Review
- Molecular Mechanisms of Ischemic Stroke: A Review Integrating Clinical Imaging and Therapeutic Perspectives.Biomedicines · 2024Review
- Intravascular ICG-enhanced NIRF-IVUS imaging to assess progressive atherosclerotic lesions in excised human coronary arteries.NPJ cardiovascular health · 2024Article
- Accounting for blood attenuation in intravascular near-infrared fluorescence-ultrasound imaging using a fluorophore-coated guidewire.Journal of biomedical optics · 2023Article
- In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications.Journal of nanobiotechnology · 2022Review
- Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.Journal of the American Heart Association · 2021Article
- Intravascular molecular-structural imaging with a miniaturized integrated near-infrared fluorescence and ultrasound catheter.Journal of biophotonics · 2021Article
- Article
- Mechanically Rotating Intravascular Ultrasound (IVUS) Transducer: A Review.Sensors (Basel, Switzerland) · 2021Review
- Article
- Paclitaxel Drug-Coated Balloon Angioplasty Suppresses Progression and Inflammation of Experimental Atherosclerosis in Rabbits.JACC. Basic to translational science · 2020Article
- Small Dimension-Big Impact! Nanoparticle-Enhanced Non-Invasive and Intravascular Molecular Imaging of Atherosclerosis In Vivo.Molecules (Basel, Switzerland) · 2020Review
- Intravascular Molecular Imaging: Near-Infrared Fluorescence as a New Frontier.Frontiers in cardiovascular medicine · 2020Review
- Cardiovascular optoacoustics: From mice to men - A review.Photoacoustics · 2019Review
- In Vivo Near-Infrared Fluorescence Imaging of Atherosclerosis Using Local Delivery of Novel Targeted Molecular Probes.Scientific reports · 2019Article
- Metabolic and Molecular Imaging of Atherosclerosis and Venous Thromboembolism.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
aims(i) to evaluate a novel hybrid near-infrared fluorescence-intravascular ultrasound (NIRF-IVUS) system in coronary and peripheral swine arteries in vivo; (ii) to assess simultaneous quantitative biological and morphological aspects of arterial disease. METHODS AND
resultsTwo 9F/15MHz peripheral and 4.5F/40MHz coronary near-infrared fluorescence (NIRF)-IVUS catheters were engineered to enable accurate co-registrtation of biological and morphological readings simultaneously in vivo. A correction algorithm utilizing IVUS information was developed to account for the distance-related fluorescence attenuation due to through-blood imaging. Corrected NIRF (cNIRF)-IVUS was applied for in vivo imaging of angioplasty-induced vascular injury in swine peripheral arteries and experimental fibrin deposition on coronary artery stents, and of atheroma in a rabbit aorta, revealing feasibility to intravascularly assay plaque structure and inflammation. The addition of ICG-enhanced NIRF assessment improved the detection of angioplasty-induced endothelial damage compared to standalone IVUS. In addition, NIRF detection of coronary stent fibrin by in vivo cNIRF-IVUS imaging illuminated stent pathobiology that was concealed on standalone IVUS. Fluorescence reflectance imaging and microscopy of resected tissues corroborated the in vivo findings.
conclusionsIntegrated cNIRF-IVUS enables simultaneous co-registered through-blood imaging of disease related morphological and biological alterations in coronary and peripheral arteries in vivo. Clinical translation of cNIRF-IVUS may significantly enhance knowledge of arterial pathobiology, leading to improvements in clinical diagnosis and prognosis, and helps to guide the development of new therapeutic approaches for arterial diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.