Evidence map›Paper›PMID 28031207›Full record

ArticleAntimicrobial agents and chemotherapy2017

Pharmacokinetics/Pharmacodynamics of Pulmonary Delivery of Colistin against Pseudomonas aeruginosa in a Mouse Lung Infection Model.

Yu-Wei Lin, Qi Tony Zhou, Soon-Ee Cheah, Jinxin Zhao, Ke Chen, Jiping Wang, Hak-Kim Chan, Jian Li

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  11. Efficacy of antibiotic combinations in an experimental sepsis model with Pseudomonas aeruginosa.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yu-Wei LinAdvanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia.
Qi Tony ZhouDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, USA tonyzhou@purdue.edu kim.chan@sydney.edu.au.
Soon-Ee CheahDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, Australia.
Jinxin ZhaoDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, Australia.
Ke ChenDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, Australia.
Jiping WangDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, Australia.
Hak-Kim ChanAdvanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia tonyzhou@purdue.edu kim.chan@sydney.edu.au.
Jian LiDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, Australia.
Monash University · AUUniversity of Sydney · AUAustralian Regenerative Medicine Institute · AUPurdue University West Lafayette · US

Funding

New Tricks for 'Old' Drugs: PK/PD of Polymyxin Nonantibiotic CombinationsR01AI111965 · NIAID · MONASH UNIVERSITY · PI LI, JIAN · 2014 to 2018
$4.3M
Targeting superbugs: discovery and development of new broad-spectrum lipopeptidesR01AI098771 · NIAID · MONASH UNIVERSITY · PI LI, JIAN · 2012 to 2016
$4.3M
NIAID NIH HHS R01 AI098771NIAID NIH HHS R01 AI111965
6 · The paper itself

Abstract

Colistin is often administered by inhalation and/or the parenteral route for the treatment of respiratory infections caused by multidrug-resistant (MDR)

Indexed as

Models, StatisticalAdministration, InhalationAnimalsAnti-Bacterial AgentsArea Under CurveBiological AvailabilityBody Mass IndexBronchoalveolar Lavage FluidColistinCyclophosphamideDisease Models, AnimalDrug Administration ScheduleDrug Dosage CalculationsHumansIntubation, IntratrachealLungAnti-Bacterial AgentsColistinCyclophosphamidecolistinintratracheal administrationmouse lung infection modelmultidrug-resistant bacteriapharmacodynamicspharmacokineticsPseudomonas aeruginosarespiratory tract infection

Identifiers

PMID28031207
PMCPMC5328518
OpenAlexW2563139642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.