Evidence map›Paper›PMID 28031201›Full record

ArticleAntimicrobial agents and chemotherapy2017

Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne

Ryan K Shields, Liang Chen, Shaoji Cheng, Kalyan D Chavda, Ellen G Press, Avin Snyder, Ruchi Pandey, Yohei Doi, Barry N Kreiswirth, M Hong Nguyen and 1 more

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 305 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
305citing papers in PubMed, 1 pooled it
20.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

305 citing papers in PubMed, 1 synthesis or guideline pooled it, 481 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Addressing therapeutic options for KPC-3-producing ST307-Antimicrobial agents and chemotherapy · 2026
    Article
  4. Clonal dissemination and plasmid plasticity of KPC-3-producing Klebsiella pneumoniae ST512 during a hospital outbreak in Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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  5. Review
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  13. Antimicrobial agents and chemotherapy · 2026
    Article
  14. Article
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  16. Article
  17. TheFrontiers in cellular and infection microbiology · 2026
    Article
  18. Article
  19. Emergence ofbioRxiv : the preprint server for biology · 2025
    Article
  20. Article

245 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ryan K ShieldsDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Liang ChenPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Shaoji ChengDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kalyan D ChavdaPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Ellen G PressDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Avin SnyderDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ruchi PandeyPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Yohei DoiDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Barry N KreiswirthPublic Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
M Hong NguyenDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA mhn5@pitt.edu.
Cornelius J ClancyDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USRutgers, The State University of New Jersey · USUniversity of Pittsburgh Medical Center · US

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
The molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2M
Caspofungin pharmacokinetics-pharmacodynamics during intra-adbominal candidiasisK08AI114883 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2015 to 2019
$858k
Evolution of KPC-K pneumoniae that persist in patients on prolonged antibioticsR21AI111037 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLANCY, CORNELIUS J · 2015 to 2016
$465k
Genomic variation in epidemic carbapenem-resistant K.pneumoniaeR21AI117338 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHEN, LIANG · 2016 to 2017
$437k
NIAID NIH HHS K08 AI114883NIAID NIH HHS R01 AI090155NIAID NIH HHS R21 AI111037NIAID NIH HHS R21 AI117338NIAID NIH HHS UM1 AI104681
6 · The paper itself

Abstract

Ceftazidime-avibactam is a novel β-lactam/β-lactamase inhibitor with activity against carbapenem-resistant

Indexed as

Genome, BacterialAgedAmino Acid SubstitutionAnti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-Lactamasesbeta-Lactam ResistanceCefepimeCeftazidimeCeftriaxoneCephalosporinsCloning, MolecularDrug CombinationsEscherichia coliFemaleAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-lactamase KPC-3, Klebsiella pneumoniaebeta-LactamasesCefepimeCeftazidimeCeftriaxoneCephalosporinsDrug CombinationsMeropenemRecombinant ProteinsThienamycinscarbapenem-resistant Enterobacteriaceaeceftazidime-avibactamKlebsiella pneumoniaeKlebsiella pneumoniae carbapenemaseresistancesequence type 258

Identifiers

PMID28031201
PMCPMC5328542
OpenAlexW2565726837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.