Evidence map›Paper›PMID 28031196›Full record

ArticleAntimicrobial agents and chemotherapy2017

Nanotized Curcumin and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis.

Brajendra Tiwari, Richa Pahuja, Pradeep Kumar, Srikanta Kumar Rath, Kailash Chand Gupta, Neena Goyal

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. In Vitro Assessment of the Combined Activity of Amphotericin B and CuTropical medicine and infectious disease · 2025
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  16. Effects of Curcumin and Its Analogues on Infectious Diseases.Advances in experimental medicine and biology · 2021
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Brajendra TiwariDivision of Biochemistry, CSIR-Central Drug Research Institute, Janki-Puram Vistar, Lucknow, India.
Richa PahujaNucleic Acids Research Lab, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Pradeep KumarNucleic Acids Research Lab, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Srikanta Kumar RathDivision of Toxicology, CSIR-Central Drug Research Institute, Janki-Puram Vistar, Lucknow, India.
Kailash Chand GuptaNucleic Acids Research Lab, CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Neena GoyalDivision of Biochemistry, CSIR-Central Drug Research Institute, Janki-Puram Vistar, Lucknow, India neenacdri@yahoo.com.
Central Drug Research Institute · INInstitute of Genomics and Integrative Biology · INAcademy of Scientific and Innovative Research · INIndian Institute of Technology Kanpur · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis chemotherapy remains very challenging due to high cost of the drug and its associated toxicity and drug resistance, which develops over a period of time. Combination therapies (CT) are now in use to treat many diseases, such as cancer and malaria, since it is more effective and affordable than monotherapy. CT are believed to represent a new explorable strategy for leishmaniasis, a neglected tropical disease caused by the obligate intracellular parasite

Indexed as

Administration, OralAnimalsAntiprotozoal AgentsCell ProliferationCricetinaeCurcuminDisease Models, AnimalDrug CarriersDrug CombinationsDrug ResistanceDrug SynergismHumansLeishmania donovaniLeishmaniasis, VisceralLymphocytesMaleAntiprotozoal AgentsCurcuminDrug CarriersDrug CombinationsmiltefosinePhosphorylcholineReactive Nitrogen SpeciesReactive Oxygen Speciescombination therapycurcuminin vivo efficacyLeishmania donovanimiltefosinenanocurcuminoral nanoparticle-based formulation

Identifiers

PMID28031196
PMCPMC5328520
OpenAlexW2564113516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.