Evidence map›Paper›PMID 28031160›Full record

ArticleAmerican journal of physiology. Cell physiology2017

Myelo-erythroid commitment after burn injury is under β-adrenergic control via MafB regulation.

Shirin Hasan, Nicholas B Johnson, Michael J Mosier, Ravi Shankar, Peggie Conrad, Andrea Szilagyi, Richard L Gamelli, Kuzhali Muthumalaiappan

Open access · greenAbstract readCase Reports
In one paragraph

Article in American journal of physiology. Cell physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. IL-1/MyD88-Dependent G-CSF and IL-6 Secretion Mediates Postburn Anemia.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Transient Improvement in Erythropoiesis Is Achieved Via the Chaperone AHSP With Early Administration of Propranolol in Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2021
    Article
  9. Article
  10. Adrenergic Modulation of Hematopoiesis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  11. Review
  12. Article
  13. Article
  14. The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.American journal of respiratory and critical care medicine · 2018
    Observational
  15. Terminal Maturation of Orthochromatic Erythroblasts Is Impaired in Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2018
    Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shirin HasanDepartment of Surgery, Loyola University Chicago, Health Sciences Division, Maywood, Illinois; and.
Nicholas B JohnsonDepartment of Surgery, Loyola University Chicago, Health Sciences Division, Maywood, Illinois; and.
Michael J MosierDepartment of Surgery, Loyola University Chicago, Health Sciences Division, Maywood, Illinois; and.
Ravi ShankarDepartment of Surgery, Loyola University Chicago, Health Sciences Division, Maywood, Illinois; and.
Peggie ConradDepartment of Surgery, Loyola University Chicago, Health Sciences Division, Maywood, Illinois; and.
Andrea SzilagyiBurn and Shock Trauma Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, Illinois.
Richard L GamelliDepartment of Surgery, Loyola University Chicago, Health Sciences Division, Maywood, Illinois; and.
Kuzhali MuthumalaiappanDepartment of Surgery, Loyola University Chicago, Health Sciences Division, Maywood, Illinois; and kmuthu@luc.edu.
Loyola University Chicago · US

Funding

TRAINING IN TRAUMA AND BURN RESEARCHT32GM008750 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI CHOUDHRY, MASHKOOR A, GONZALEZ, RICHARD PAUL · 2000 to 2023
$2.9M
Mechanisms of Impaired Erythropoiesis in Post Burn Anemia of Critical IllnessR01DK097760 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI MUTHUMALAIAPPAN, KUZHALI · 2013 to 2017
$1.1M
NIDDK NIH HHS R01 DK097760NIGMS NIH HHS T32 GM008750
6 · The paper itself

Abstract

Severely injured burn patients receive multiple blood transfusions for anemia of critical illness despite the adverse consequences. One limiting factor to consider alternate treatment strategies is the lack of a reliable test platform to study molecular mechanisms of impaired erythropoiesis. This study illustrates how conditions resulting in a high catecholamine microenvironment such as burns can instigate myelo-erythroid reprioritization influenced by β-adrenergic stimulation leading to anemia. In a mouse model of scald burn injury, we observed, along with a threefold increase in bone marrow LSK cells (lin

Indexed as

AdultAnimalsBurnsCell DifferentiationCellular MicroenvironmentErythrocytesFemaleHumansMafB Transcription FactorMaleMiceMiddle AgedMyeloid CellsReceptors, Adrenergic, betaMafb protein, mouseMafB Transcription FactorReceptors, Adrenergic, betaanemiaburnscatecholamineerythro-myeloiderythropoiesisgranulocyte monocyte progenitorsLSK cellsMafBmegakaryocyte erythrocyte progenitorspropranolol

Identifiers

PMID28031160
PMCPMC5401945
OpenAlexW2564504547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.