Evidence map›Paper›PMID 28031039›Full record

Trial reportTrials2016

Attention training for infants at familial risk of ADHD (INTERSTAARS): study protocol for a randomised controlled trial.

Amy Goodwin, Simona Salomone, Patrick Bolton, Tony Charman, Emily J H Jones, Luke Mason, Andrew Pickles, Emily Robinson, Tim Smith, Edmund J S Sonuga-Barke and 2 more

Erratum issuedOpen access · goldAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Attention-deficit hyperactivity disorder.Lancet (London, England) · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Future Directions for Infant Identification and Intervention for Autism Spectrum Disorder from a Transdiagnostic Perspective.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Amy GoodwinDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK. amy.goodwin@kcl.ac.uk.ORCID 0000-0003-2585-8452
Simona SalomoneCentre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
Patrick BoltonDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
Tony CharmanDepartment of Psychology, IoPPN, King's College London, London, UK.
Emily J H JonesCentre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
Luke Mason
Andrew PicklesDepartment of Biostatistics, IoPPN, King's College London, London, UK.
Emily RobinsonDepartment of Biostatistics, IoPPN, King's College London, London, UK.
Tim SmithDepartment of Psychological Sciences, Birkbeck, University of London, London, UK.
Edmund J S Sonuga-BarkeDepartment of Psychology, University of Southampton, Southampton, UK.
Sam WassSchool of Psychology, University of East London, London, UK.
Mark H JohnsonCentre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
King's College London · GBBirkbeck, University of London · GBGhent University Hospital · BEUniversity of East London · GB

Funding

Medical Research Council G0701484Medical Research Council MR/K021389/1
6 · The paper itself

Abstract

backgroundAttention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder that can negatively impact on an individual's quality of life. It is pathophysiologically complex and heterogeneous with different neuropsychological processes being impaired in different individuals. Executive function deficits, including those affecting attention, working memory and inhibitory control, are common. Cognitive training has been promoted as a treatment option, based on the notion that by strengthening the neurocognitive networks underlying these executive processes, ADHD symptoms will also be reduced. However, if implemented in childhood or later, when the full disorder has become well-established, cognitive training has only limited value. INTERSTAARS is a trial designed to test a novel approach to intervention, in which cognitive training is implemented early in development, before the emergence of the disorder. The aim of INTERSTAARS is to train early executive skills, thereby increasing resilience and reducing later ADHD symptoms and associated impairment. METHODS/

designFifty 10-14-month-old infants at familial risk of ADHD will participate in INTERSTAARS. Infants will be randomised to an intervention or a control group. The intervention aims to train early attention skills by using novel eye-tracking technology and gaze-contingent training paradigms. Infants view animated games on a screen and different events take place contingent on where on the screen the infant is looking. Infants allocated to the intervention will receive nine weekly home-based attention training sessions. Control group infants will also receive nine weekly home visits, but instead of viewing the training games during these visits they will view non-gaze-contingent age-appropriate videos. At baseline and post treatment, infant attention control will be assessed using a range of eye-tracking, observational, parent-report and neurophysiological measures. The primary outcome will be a composite of eye-tracking tasks used to assess infant attention skills. Follow-up data will be collected on emerging ADHD symptoms when the infants are 2 and 3 years old. DISCUSSION: This is the first randomised controlled trial to assess the potential efficacy of cognitive training as a prevention measure for infants at familial risk of ADHD. If successful, INTERSTAARS could offer a promising new approach for developing early interventions for ADHD.

trial registrationInternational Standard Randomised Controlled Trial registry: ISRCTN37683928 . Registered on 22 June 2015.

Indexed as

AttentionChild DevelopmentInfant BehaviorPsychology, ChildVideo GamesAge FactorsAttention Deficit Disorder with HyperactivityChild, PreschoolClinical ProtocolsCognitionCognitive Behavioral TherapyDouble-Blind MethodEarly Medical InterventionExecutive FunctionFemaleGenetic Predisposition to DiseaseADHDAttentionCognitive trainingEarly interventionFamilial riskInfancy

Identifiers

PMID28031039
PMCPMC5192597
OpenAlexW2566114807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.