SynthesisOncotarget2017
Systematic review of resecting primary tumor in MNETs patients with unresectable liver metastases.
Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Review
- How to Manage Small Intestine (Jejunal and Ileal) Neuroendocrine Neoplasms Presenting with Liver Metastases?Current oncology reports · 2021Review
- Surgical Principles in the Management of Small Bowel Neuroendocrine Tumors.Current treatment options in oncology · 2020Review
- High-grade well-differentiated neuroendocrine tumour of the cecum diagnosed following incisional hernia repair: a case report.Acta medica Lituanic · 2020Article
- [Metastasized intestinal neuroendocrine tumors: Surgery for ileus prophylaxis].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019Article
- Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism.International journal of endocrinology · 2019Article
- [Surgical aspects of neuroendocrine tumors of the small intestine].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Review
- [Metastasized intestinal neuroendocrine tumors: Surgery for ileus prophylaxis].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Article
- Role of palliative resection of the primary pancreatic neuroendocrine tumor in patients with unresectable metastatic liver disease: a systematic review and meta-analysis.OncoTargets and therapy · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatment for midgut neuroendocrine tumor patients with unresectable liver metastasis has long been a controversial issue. This system review aims to summarize existing evidence concerning the value of primary tumor resection in this group of patients.
results8 cohort studies were identified for qualitative analysis. None of them strictly met with the inclusion criteria and meta-analysis was impossible. There was a tendency towards better overall survival for the primary tumor resected group in all 8 studies, in which 6 demonstrated significant difference. Progression free survival to liver disease was prolonged and less patients died of liver failure in the resected group.
methodsMEDLINE, EMBASE and CENTRAL were searched until 2016/7/4 for relevant studies, with primary outcome being overall survival, and secondary outcome being progression free survival, cause of death and symptom relief.
conclusionsCurrent evidence supports resection of primary tumor for midgut neuroendocrine tumor patients with liver metastases, but randomized controlled trials are required to reach a final conclusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.