ArticlePloS one2016
Time Course of Leptin in Patients with Anorexia Nervosa during Inpatient Treatment: Longitudinal Relationships to BMI and Psychological Factors.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Lack of association between leptin concentrations and cystic fibrosis: A meta-analysis and regression.Frontiers in endocrinology · 2023Pooled it
- Olfaction is a Marker of Severity but Not Diagnosis in Anorexia Nervosa: a Systematic Review and Meta-Analysis.Neuropsychology review · 2020Pooled it
- Activity Based Anorexia as an Animal Model for Anorexia Nervosa-A Systematic Review.Frontiers in nutrition · 2019Pooled it
- Transcranial Direct Current Stimulation in Anorexia Nervosa: A Randomized Sham-Controlled Trial.Journal of clinical medicine · 2026Article
- Exploring the Genetic Overlap Between Metabolic Traits and Anorexia Nervosa.Biological psychiatry global open science · 2026Article
- Biological aging analysis based on DNA methylation status for social anxiety disorder.Neuropsychopharmacology reports · 2024Article
- Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa.Psychiatry and clinical neurosciences · 2024Article
- PCSK9 and leptin plasma levels in anorexia nervosa.Hormones (Athens, Greece) · 2024Observational
- The Association between Blood SIRT1 and Ghrelin, Leptin, and Antibody Anti-Hypothalamus: A Comparison in Normal Weight and Anorexia Nervosa.Journal of personalized medicine · 2023Article
- Anti-hypothalamus autoantibodies in anorexia nervosa: a possible new mechanism in neuro-physiological derangement?Eating and weight disorders : EWD · 2022Article
- Serum leptin and neuropeptide Y in patients with cystic fibrosis-A single center study.Frontiers in medicine · 2022Article
- Role of Neuroendocrine, Immune, and Autonomic Nervous System in Anorexia Nervosa-Linked Cardiovascular Diseases.International journal of molecular sciences · 2020Review
- Emotional intelligence, empathy and alexithymia in anorexia nervosa during adolescence.Eating and weight disorders : EWD · 2020Article
- MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update.European journal of endocrinology · 2019Review
- Neuropsychological and Cognitive Correlates of Recovery in Anorexia Nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2017Article
- Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment.PloS one · 2017Article
- Salivary BDNF to predict at-risk status of eating disorders in young nutritionist Jordanian females: Results from a preliminary multistage study.Women's health (London, England)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeptin, a hormone secreted by adipose tissue, appears to play a major role in the homeostasis of body weight and psychobiological processes associated with anorexia nervosa (AN). However, there is scarce data on its exact influence on this disorder, in particular data over time.
objectiveThe present study addresses whether leptin changes during inpatient treatment play a role for treatment outcome and psychological factors in underweight AN patients.
methodsIn order to understand whether leptin's role differs in relation to AN severity, data were assessed from 11 patients with a very low BMI and a higher chronicity (high severity group; HSS; mean BMI at the beginning of the study = 13.6; mean duration of illness = 5.1 years) vs. nine with less severe symptoms (LSS; mean BMI = 16.2; mean duration of illness = 3.7 years). During the course of treatment, serum leptin concentrations were assessed weekly while weight (BMI) was assessed twice per week. Concomitantly, psychological variables were obtained by means of electronic diaries. Unconditional linear growth models were calculated to evaluate the temporal course of leptin in relation to BMI. For HSS patients, two phases of treatment (BMI < 16 and BMI ≥ 16 kg/m2) were investigated.
resultsLeptin increased significantly with BMI in both groups of patients. For HSS patients, the increase of leptin in the first treatment phase did not predict later increases in BMI. Furthermore, the relationship of leptin and psychological factors was modulated by symptom severity. In HSS patients, higher leptin levels were associated with greater feelings of depression, anxiety, and stress whereas in LSS patients a higher leptin level showed the trend to be associated with lower psychological symptom burden.
conclusionsOur results suggest that leptin changes are differently associated with weight gain and psychological symptoms depending on the severity of starvation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.