ArticlePain2017
Intense pain influences the cortical processing of visual stimuli projected onto the sensitized skin.
Article in Pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Cannabinoid Analgesia in Postoperative Pain Management: From Molecular Mechanisms to Clinical Reality.International journal of molecular sciences · 2024Review
- Extensive sensorimotor training enhances nociceptive cortical responses in healthy individuals.European journal of pain (London, England) · 2023Article
- The influence of a manipulation of threat on experimentally-induced secondary hyperalgesia.PeerJ · 2022Article
- Perceptual correlates of homosynaptic long-term potentiation in human nociceptive pathways: a replication study.Royal Society open science · 2021Article
- Cortical plasticity in phantom limb pain: A fMRI study on the neural correlates of behavioral clinical manifestations.Psychiatry research. Neuroimaging · 2020Article
- No evidence of widespread mechanical pressure hyperalgesia after experimentally induced central sensitization through skin nociceptors.Pain reports · 2018Article
- Polarity-specific modulation of pain processing by transcranial direct current stimulation - a blinded longitudinal fMRI study.The journal of headache and pain · 2018Article
- No perceptual prioritization of non-nociceptive vibrotactile and visual stimuli presented on a sensitized body part.Scientific reports · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Sensitization is a form of implicit learning produced by the exposure to a harmful stimulus. In humans and other mammals, sensitization after skin injury increases the responsiveness of peripheral nociceptors and enhances the synaptic transmission of nociceptive input in the central nervous system. Here, we show that sensitization-related changes in the central nervous system are not restricted to nociceptive pathways and, instead, also affect other sensory modalities, especially if that modality conveys information relevant for the sensitized body part. Specifically, we show that after sensitizing the forearm using high-frequency electrical stimulation (HFS) of the skin, visual stimuli projected onto the sensitized forearm elicit significantly enhanced brain responses. Whereas mechanical hyperalgesia was present both 20 and 45 minutes after HFS, the enhanced responsiveness to visual stimuli was present only 20 minutes after HFS. Taken together, our results indicate that sensitization involves both nociceptive-specific and multimodal mechanisms, having distinct time courses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.