Evidence map›Paper›PMID 28030471›Full record

ArticlePain2017

Stress-related psychological symptoms contribute to axial pain persistence after motor vehicle collision: path analysis results from a prospective longitudinal study.

Rose K Feinberg, JunMei Hu, Mark A Weaver, Roger B Fillingim, Robert A Swor, David A Peak, Jeffrey S Jones, Niels K Rathlev, David C Lee, Robert M Domeier and 3 more

Abstract read
In one paragraph

Article in Pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rose K FeinbergUNC Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, USA.
JunMei HuUNC Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, USA.
Mark A WeaverMedicine and Biostatistics, University of North Carolina, Chapel Hill, NC, USA.
Roger B FillingimDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, USA.
Robert A SworDepartment of Emergency Medicine, William Beaumont Hospital, Royal Oak, MI, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jeffrey S JonesDepartment of Emergency Medicine, Spectrum Health System, Grand Rapids, MI, USA.
Niels K RathlevDepartment of Emergency Medicine, Baystate Medical Center, Springfield, MA, USA.
David C LeeDepartment of Emergency Medicine, North Shore University Hospital, Manhasset, NY, USA.
Robert M DomeierDepartment of Emergency Medicine, Saint Joseph Mercy Health System, Ypsilanti, MI, USA.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida, Jacksonville, FL, USA.
Israel LiberzonDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Samuel A McLeanUNC Institute for Trauma Recovery, University of North Carolina, Chapel Hill, NC, USA.

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Karyn A Esser, Todd Manini · 2007 to 2026
$22.8M
Applying Biopsychosocial Model to Post-MVC Pain Development in African AmericansR01AR060852 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCLEAN, SAMUEL A. · 2011 to 2015
$3.6M
Genetic Predictors of Acute and Chronic Musculoskeletal Pain After Minor MVCR01AR056328 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCLEAN, SAMUEL A. · 2008 to 2011
$2.9M
Development of Chronic Pain After Motor Vehicle TraumaK23AR050410 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCLEAN, SAMUEL A. · 2006 to 2008
$385k
NCATS NIH HHS UL1 TR001111NIAMS NIH HHS K23 AR050410NIAMS NIH HHS R01 AR056328NIAMS NIH HHS R01 AR060852NIA NIH HHS P30 AG028740
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) symptoms and pain after traumatic events such as motor vehicle collision (MVC) have been proposed to be mutually promoting. We performed a prospective multicenter study that enrolled 948 individuals who presented to the emergency department within 24 hours of MVC and were discharged home after evaluation. Follow-up evaluations were completed 6 weeks, 6 months, and 1 year after MVC. Path analysis results supported the hypothesis that axial pain after MVC consistently promotes the maintenance of hyperarousal and intrusive symptoms, from the early weeks after injury through 1 year. In addition, path analysis results supported the hypothesis that one or more PTSD symptom clusters had an influence on axial pain outcomes throughout the year after MVC, with hyperarousal symptoms most influencing axial pain persistence in the initial months after MVC. The influence of hyperarousal symptoms on pain persistence was only present among individuals with genetic vulnerability to stress-induced pain, suggesting specific mechanisms by which hyperarousal symptoms may lead to hyperalgesia and allodynia. Further studies are needed to better understand the specific mechanisms by which pain and PTSD symptoms enhance one another after trauma, and how such mechanisms vary among specific patient subgroups, to better inform the development of secondary preventive interventions.

Indexed as

Accidents, TrafficAdolescentAdultAgedFactor Analysis, StatisticalFemaleGenotyping TechniquesHumansLongitudinal StudiesMaleMiddle AgedPainPain MeasurementPsychiatric Status Rating ScalesRetrospective StudiesStress Disorders, Post-TraumaticTacrolimus Binding Protein 5Tacrolimus Binding Proteins

Identifiers

PMID28030471
PMCPMC5354970

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.