Evidence map›Paper›PMID 28030470›Full record

Trial reportPain2017

Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial.

Timothy R Deer, Robert M Levy, Jeffery Kramer, Lawrence Poree, Kasra Amirdelfan, Eric Grigsby, Peter Staats, Allen W Burton, Abram H Burgher, Jon Obray and 18 more

2 registry-linked trialsOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 211 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
211citing papers in PubMed, 12 pooled it
48.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04727216 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Intermittent Dorsal Root Ganglion Stimulation Dosing Comparison to Standard Continuous Dosing in Treating Chronic Pain

TypeinterventionalSponsorSpine and Pain Institute of New YorkRan2021 to 2021Enrolled15ConditionsPain, Intractable, Pain, ChronicArmsDorsal Root Ganglion Stimulation (DRG-S)
NCT07170722 nacompletednot on this mapstarted 2025, after this paper: background citation

Efficacy of Sub-Threshold Dorsal Root Ganglion (DRG) Stimulation Versus Sham in Established Responders: A Randomised, Double-Blind, Two-Period Crossover Trial

TypeinterventionalSponsorUmeå UniversityRan2025 to 2025Enrolled20ConditionsNeuropathic Pain, Complex Regional Pain Syndromes (CRPS), Causalgia, Chronic PainArmsSubtreshhold DRG-S, Sham
3 · Its place in the literature

Who cites it

211 citing papers in PubMed, 12 syntheses or guidelines pooled it, 593 citations in OpenAlex.

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  10. Implanted spinal neuromodulation interventions for chronic pain in adults.The Cochrane database of systematic reviews · 2021
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151 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 15 institutions in 1 country.

Timothy R DeerCenter for Pain Relief, Charleston, WV, USA.
Robert M LevyMarcus Neuroscience Institute, Boca Raton, FL, USA.
Jeffery KramerSt. Jude Medical, Sunnyvale, CA and Plano, TX, USA.
Lawrence PoreeUniversity of California, San Francisco, San Francisco, CA, USA.
Kasra AmirdelfanIPM Medical Group, Inc, Walnut Creek, CA, USA.
Eric GrigsbyNeurovations, Napa, CA, USA.
Peter StaatsPremier Pain Center, Shrewsbury Township, NJ, USA.
Allen W BurtonHouston Pain Centers, Houston, TX, USA.
Abram H BurgherHOPE Research-TPC, Phoenix, AZ, USA.
Jon ObrayHOPE Research-LVSP, Las Vegas, NV, USA.
James ScowcroftPain Management Associates, Independence, MO, USA.
Stan GolovacFlorida Pain, Merritt Island, FL, USA.
Leonardo KapuralCarolinas Pain Institute, Winston-Salem, NC, USA.
Richard PaiciusNewport Beach Headache and Pain, Newport Beach, CA, USA.
Christopher KimCenter for Pain Relief, Charleston, WV, USA.
Jason PopeCenter for Pain Relief, Charleston, WV, USA.
Thomas YearwoodComprehensive Pain and Rehabilitation, Pascagoula, MS, USA.
Sam SamuelCleveland Clinic, Cleveland, OH, USA.
W Porter McRobertsHoly Cross Hospital, Ft. Lauderdale, FL, USA.
Hazmer CassimEisenhower Medical Center, Rancho Mirage, CA, USA.
Mark NethertonSoutheastern Spine Institute, Mt. Pleasant, SC, USA.
Nathan MillerCoastal Pain Research, Carlsbad, CA, USA.
Michael SchaufeleDrug Studies America, Marietta, GA, USA.
Edward TavelClinical Trials of South Carolina, Charleston, SC, USA.
Timothy DavisOrthopaedic Pain Specialists, Santa Monica, CA, USA.
Kristina DavisSt. Jude Medical, Sunnyvale, CA and Plano, TX, USA.
Linda JohnsonSt. Jude Medical, Sunnyvale, CA and Plano, TX, USA.
Nagy MekhailCleveland Clinic, Cleveland, OH, USA.
St. Jude Medical Center · USCleveland Clinic · USBoca Raton Regional Hospital · USCarolinas Pain Institute · USClinical Trials of South Carolina · USDrug Studies America · USEisenhower Medical Center · USFlorida Pain Institute · USHoly Cross Hospital · USHouston Medical Center · USMedical Advanced Pain Specialists · USPain and Rehabilitation Medicine · USPain Management Institute · USSoutheastern Spine Center & Research Institute · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animal and human studies indicate that electrical stimulation of dorsal root ganglion (DRG) neurons may modulate neuropathic pain signals. ACCURATE, a pivotal, prospective, multicenter, randomized comparative effectiveness trial, was conducted in 152 subjects diagnosed with complex regional pain syndrome or causalgia in the lower extremities. Subjects received neurostimulation of the DRG or dorsal column (spinal cord stimulation, SCS). The primary end point was a composite of safety and efficacy at 3 months, and subjects were assessed through 12 months for long-term outcomes and adverse events. The predefined primary composite end point of treatment success was met for subjects with a permanent implant who reported 50% or greater decrease in visual analog scale score from preimplant baseline and who did not report any stimulation-related neurological deficits. No subjects reported stimulation-related neurological deficits. The percentage of subjects receiving ≥50% pain relief and treatment success was greater in the DRG arm (81.2%) than in the SCS arm (55.7%, P < 0.001) at 3 months. Device-related and serious adverse events were not different between the 2 groups. Dorsal root ganglion stimulation also demonstrated greater improvements in quality of life and psychological disposition. Finally, subjects using DRG stimulation reported less postural variation in paresthesia (P < 0.001) and reduced extraneous stimulation in nonpainful areas (P = 0.014), indicating DRG stimulation provided more targeted therapy to painful parts of the lower extremities. As the largest prospective, randomized comparative effectiveness trial to date, the results show that DRG stimulation provided a higher rate of treatment success with less postural variation in paresthesia intensity compared to SCS.

Indexed as

AdultAgedCausalgiaComplex Regional Pain SyndromesElectric Stimulation TherapyFemaleFollow-Up StudiesGanglia, SpinalHumansMaleMiddle AgedPain MeasurementPsychiatric Status Rating ScalesYoung Adult

Identifiers

PMID28030470
PMCPMC5359787
OpenAlexW2564952377

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.