ReviewCurrent opinion in allergy and clinical immunology2017
Microbes, allergic sensitization, and the natural history of asthma.
Review in Current opinion in allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood.The journal of allergy and clinical immunology. In practice · 2019Trial
- Allergic sensitization and respiratory infection in infancy-Too early for two-hits on lung function?Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- The epigenetic-immune-microbiome axis in early life: reprogramming the origins and endotypes of pediatric asthma.Frontiers in immunology · 2026Review
- Environmental and structural factors associated with bacterial diversity in household dust across the Arizona-Sonora border.Scientific reports · 2024Article
- Environmental and Structural Factors Associated with Bacterial Diversity in Household Dust Across the Arizona-Sonora Border.Research square · 2023Article
- The association of polyunsaturated fatty acids and asthma: a cross-sectional study.Journal of health, population, and nutrition · 2023Article
- The Role ofInternational journal of molecular sciences · 2022Review
- The Environmental Microbiome, Allergic Disease, and Asthma.The journal of allergy and clinical immunology. In practice · 2022Article
- The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women.International journal of environmental research and public health · 2022Article
- The nasal microbiome, nasal transcriptome, and pet sensitization.The Journal of allergy and clinical immunology · 2021Article
- Longitudinal Asthma Patterns in Italian Adult General Population Samples: Host and Environmental Risk Factors.Journal of clinical medicine · 2020Article
- Asthma and Indoor Environment: Usefulness of a Global Allergen Avoidance Method on Asthma Control and Exposure to Molds.Mycopathologia · 2020Article
- Metagenomic Characterization of Indoor Dust Bacterial and Fungal Microbiota in Homes of Asthma and Non-asthma Patients Using Next Generation Sequencing.Frontiers in microbiology · 2020Article
- T cells in severe childhood asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewUnderstanding factors that lead to asthma development in early life is essential to developing strategies aimed at primary or secondary prevention. RECENT
findingsThis article will review current evidence addressing the development of early life allergic sensitization in relation to microbes and the gut and airway microbiome. Wheezing illnesses, particularly viral, remain a significant risk factor for asthma inception; however, bacterial pathogens have recently emerged as an additional important contributor to asthma risk, either alone or as cofactors with viral infections. The combined influence and interaction of early life viral wheezing and aeroallergen sensitization is important, with allergic sensitization preceding the onset of viral wheeze. Lastly, we review recent data from longitudinal studies regarding the development of irreversible airway obstruction and its impact on the natural history of asthma. SUMMARY: The development of asthma remains complex and incompletely understood. There is interplay between genetic predisposition and environmental exposures, including allergens and microbes. Interventions aimed at these risk factors during the preschool years may prevent the longitudinal course of asthma progression to irreversible airway obstruction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.