ArticleAddiction (Abingdon, England)2017
A SMART data analysis method for constructing adaptive treatment strategies for substance use disorders.
Article in Addiction (Abingdon, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02997943 (SMART Weight Loss Management), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SMART Weight Loss Management
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sequential multiple assignment randomized trial studies should report all key components: a systematic review.Journal of clinical epidemiology · 2022Pooled it
- Adaptive Intervention for School-Age, Minimally Verbal Children With Autism Spectrum Disorder in the Community: Primary Aim Results.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Trial
- Examining engagement effects in an adaptive preventive intervention for college student drinking.Journal of consulting and clinical psychology · 2023Trial
- Deeply Tailored Adaptive Interventions to Reduce College Student Drinking: a Real-World Application of Q-Learning for SMART Studies.Prevention science : the official journal of the Society for Prevention Research · 2022Trial
- Trial
- Protocol for the sequential multiple assignment randomized trial to reduce food insecurity and improve adherence in patients with hypertension (SMART-FI).Contemporary clinical trials · 2026Article
- How and when do work stressors and peer norms impact career entrants' alcohol-related behavior and its consequences?Human relations; studies towards the integration of the social sciences · 2025Article
- Developing personalized algorithms for sensing mental health symptoms in daily life.Npj mental health research · 2025Article
- Hierarchical taxonomy of psychopathology and personalized mental health treatment selection.Frontiers in psychiatry · 2025Review
- Simulating A/B testing versus SMART designs for LLM-driven patient engagement to close preventive care gaps.NPJ digital medicine · 2024Article
- Optimizing Allocation to Telehealth and In-Person Prolonged Exposure for Women Veterans with Military Sexual Trauma: A Precision Medicine Approach.Behavioral sciences (Basel, Switzerland) · 2024Article
- Design of experiments with sequential randomizations on multiple timescales: the hybrid experimental design.Behavior research methods · 2024Article
- Testing adaptive interventions to improve PTSD treatment outcomes in Federally Qualified Health Centers: Protocol for a randomized clinical trial.Contemporary clinical trials · 2023Article
- Recent innovations in adaptive trial designs: A review of design opportunities in translational research.Journal of clinical and translational science · 2023Review
- Bayesian set of best dynamic treatment regimes: Construction and sample size calculation for SMARTs with binary outcomes.Statistics in medicine · 2022Article
- Evidence of Help-Seeking Behaviors Among Black Women Under Community Supervision in New York City: A Plea for Culturally Tailored Intimate Partner Violence Interventions.Women's health reports (New Rochelle, N.Y.) · 2022Article
- MCMTC: A Pragmatic Framework for Selecting an Experimental Design to Inform the Development of Digital Interventions.Frontiers in digital health · 2022Article
- Multitiered Systems of Support, Adaptive Interventions, and SMART Designs.Exceptional children · 2021Article
- Innovative trial approaches in immune-mediated inflammatory diseases: current use and future potential.BMC rheumatology · 2021Article
- Ascertaining properties of weighting in the estimation of optimal treatment regimes under monotone missingness.Statistics in medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
aimsTo demonstrate how Q-learning, a novel data analysis method, can be used with data from a sequential, multiple assignment, randomized trial (SMART) to construct empirically an adaptive treatment strategy (ATS) that is more tailored than the ATSs already embedded in a SMART.
methodWe use Q-learning with data from the Extending Treatment Effectiveness of Naltrexone (ExTENd) SMART (N = 250) to construct empirically an ATS employing naltrexone, behavioral intervention, and telephone disease management to reduce alcohol consumption over 24 weeks in alcohol dependent individuals.
resultsQ-learning helped to identify a subset of individuals who, despite showing early signs of response to naltrexone, require additional treatment to maintain progress.
conclusionsQ-learning can inform the development of more cost-effective, adaptive treatment strategies for treating substance use disorders.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.