ArticleCortex; a journal devoted to the study of the nervous system and behavior2017
Medial temporal lobe reinstatement of content-specific details predicts source memory.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Aging shifts hippocampal reactivation from selective reinstatement to category-level misbinding during episodic memory.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Alpha Oscillations Track the Projection of Reactivated Memories into Conscious Awareness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A Toaster in the Bathroom: Neural Correlates of Semantic Construction During Episodic Memory Recall.Human brain mapping · 2025Article
- Neural Correlates of Retrieval Success and Precision: A Functional Magnetic Resonance Imaging Study.Journal of cognitive neuroscience · 2025Article
- Concurrent representations of reinstated and transformed memories and their modulation by reward.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Interoceptive and Bodily Processing in Prospective and Retrospective Timing.Current topics in behavioral neurosciences · 2025Review
- Embodiment in episodic memory through premotor-hippocampal coupling.Communications biology · 2024Article
- Neural correlates of retrieval success and precision: an fMRI study.bioRxiv : the preprint server for biology · 2024Article
- Memory reactivation and suppression modulate integration of the semantic features of related memories in hippocampus.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Sustained neural representations of personally familiar people and places during cued recall.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Article
- Category-sensitive incidental reinstatement in medial temporal lobe subregions during word recognition.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Shared Representational Formats for Information Maintained in Working Memory and Information Retrieved from Long-Term Memory.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- An engram of intentionally forgotten information.Nature communications · 2021Article
- Reinstatement of item-specific contextual details during retrieval supports recombination-related false memories.NeuroImage · 2021Article
- A single session of moderate intensity exercise influences memory, endocannabinoids and brain derived neurotrophic factor levels in men.Scientific reports · 2021Article
- When the brain, but not the person, remembers: Cortical reinstatement is modulated by retrieval goal in developmental amnesia.Neuropsychologia · 2021Article
- Enhanced reinstatement of naturalistic event memories due to hippocampal-network-targeted stimulation.Current biology : CB · 2021Article
- Hippocampal Theta Oscillations Support Successful Associative Memory Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Holistic Recollection via Pattern Completion Involves Hippocampal Subfield CA3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Decision-making Increases Episodic Memory via Postencoding Consolidation.Journal of cognitive neuroscience · 2019Article
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2 authors.
Funding
Abstract
Leading theories propose that when remembering past events, medial temporal lobe (MTL) structures reinstate the neural patterns that were active when those events were initially encoded. Accurate reinstatement is hypothesized to support detailed recollection of memories, including their source. While several studies have linked cortical reinstatement to successful retrieval, indexing reinstatement within the MTL network and its relationship to memory performance has proved challenging. Here, we addressed this gap in knowledge by having participants perform an incidental encoding task, during which they visualized people, places, and objects in response to adjective cues. During a surprise memory test, participants saw studied and novel adjectives and indicated the imagery task they performed for each adjective. A multivariate pattern classifier was trained to discriminate the imagery tasks based on functional magnetic resonance imaging (fMRI) responses from hippocampus and MTL cortex at encoding. The classifier was then tested on MTL patterns during the source memory task. We found that MTL encoding patterns were reinstated during successful source retrieval. Moreover, when participants made source misattributions, errors were predicted by reinstatement of incorrect source content in MTL cortex. We further observed a gradient of content-specific reinstatement along the anterior-posterior axis of hippocampus and MTL cortex. Within anterior hippocampus, we found that reinstatement of person content was related to source memory accuracy, whereas reinstatement of place information across the entire hippocampal axis predicted correct source judgments. Content-specific reinstatement was also graded across MTL cortex, with PRc patterns evincing reactivation of people and more posterior regions, including PHc, showing evidence for reinstatement of places and objects. Collectively, these findings provide key evidence that source recollection relies on reinstatement of past experience within the MTL network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.