ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2017
Impact of Examined Lymph Node Count on Precise Staging and Long-Term Survival of Resected Non-Small-Cell Lung Cancer: A Population Study of the US SEER Database and a Chinese Multi-Institutional Registry.
Open access · hybridAbstract readValidation Study
In one paragraph
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 230 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
230citing papers in PubMed, 2 pooled it
24.9field-weighted citation impact, top 1% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
230 citing papers in PubMed, 2 syntheses or guidelines pooled it, 354 citations in OpenAlex.
- Lobectomy versus sublobar resection for stage I non-small cell lung cancer: an umbrella review of evidence quality, overlap, surgical-extent heterogeneity, and survival outcomes.Frontiers in oncology · 2026Pooled it
- Survival After Mediastinal Node Dissection, Systematic Sampling, or Neither for Early Stage NSCLC.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2020Pooled it
- Prognostic nomogram based on the lymph node metastasis indicators for patients with bladder cancer: A SEER population-based study and external validation.Cancer medicine · 2023Trial
- Prognostic factors and survival prediction for patients with metastatic lung adenocarcinoma: A population-based study.Medicine · 2022Trial
- The nomograms for predicting overall and cancer-specific survival in elderly patients with early-stage lung cancer: A population-based study using SEER database.Frontiers in public health · 2022Trial
- Development and Validation of a Prognostic Nomogram for Lung Adenocarcinoma: A Population-Based Study.Journal of healthcare engineering · 2022Trial
- Examined lymph node count and survival in resected non-small cell lung cancer: attenuation of benefit beyond 16 nodes is confined to node-negative disease.Journal of thoracic disease · 2026Article
- Clinical performance of da Vinci 5 versus Xi for robotic anatomic lung resection: a propensity-weighted analysis.Journal of robotic surgery · 2026Article
- Extent of Endobronchial Ultrasound Nodal Sampling and Risk of Pathologic N2 Upstaging in Clinical N0-N1 Non-Small Cell Lung Cancer.Thoracic cancer · 2026Article
- The Ideal Number of Examined Lymph Node Stations for Accurate Nodal Staging and Prognosis in Pathological T1-2 Esophageal Squamous Cell Carcinoma: A Large-Scale Multicenter Cohort Study.Annals of surgical oncology · 2026Article
- The prognostic value of central excised lymph node count in N1a papillary thyroid cancer: a population-based study.Gland surgery · 2026Article
- Prognostic Impact of Inadequate Lymph Node Evaluation in Early-Stage Lung Adenocarcinoma with Micropapillary or Solid Components.Annals of surgical oncology · 2026Article
- Risk-adapted nodal evaluation in stage IA non-small cell lung cancer: a population-based competing-risk analysis.World journal of surgical oncology · 2026Article
- Uniportal Robotic-Assisted Versus Video-Assisted Thoracoscopic Surgery for Anatomical Lung Resection in Non-Small Cell Lung Cancer: A Comparative Single-Center Cohort Study.Journal of clinical medicine · 2026Article
- N-LODDS: A Novel Integrated Lymph Node Staging System Enhancing Prognostic Accuracy in Non-Small-Cell Lung Cancer.Annals of surgical oncology · 2026Article
- Prognostic Significance of the Uncertain Resection Based on the Extent of Nodal Dissection in Non-small-Cell Lung Cancer.Annals of surgical oncology · 2026Article
- Novel lipid metabolism-related gene signature associated with clinical and immune features in lung adenocarcinoma patients experiencing lymph node metastasis.Translational lung cancer research · 2026Article
- Clinicopathological characteristics, incidence trends, and prognostic factors of salivary gland secretory carcinoma: a SEER database analysis (2011-2021).European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Examined lymph node counts ≤6 are correlated with an unfavorable prognosis in stage IA NSCLC patients following sublobar resection: a retrospective study employing propensity score matching analysis.Journal of thoracic disease · 2026Article
- Development of a deep learning model based on computed tomography automatic segmentation to assist in selecting optimal time-to-surgery and dissected lymph node count for non-small cell lung cancer patients undergoing neoadjuvant immunotherapy and chemotherapy: a multicenter study.Translational lung cancer research · 2026Article
170 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors at 6 institutions in 4 countries.
Wenhua LiangWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Jiaxi HeWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Yaxing ShenWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Jianfei ShenWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Qihua HeWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Jianrong ZhangWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Gening JiangWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Qun WangWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Lunxu LiuWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Shugeng GaoWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Deruo LiuWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Zheng WangWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Zhihua ZhuWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Calvin S H NgWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Chia-Chuan LiuWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
René Horsleben PetersenWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Gaetano RoccoWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Thomas D'AmicoWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Alessandro BrunelliWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Haiquan ChenWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Xiuyi ZhiWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Bo LiuWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Yixin YangWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Wensen ChenWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Qian ZhouWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
Jianxing HeWenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, The First Affiliated Hospital of Guangzhou Medical University; Wenhua Liang, Jiaxi He, Jianfei Shen, Qihua He, Jianrong Zhang, and Jianxing He, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease; Zhihua Zhu, Cancer Center of Sun Yat-Sen University; Qian Zhou, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou; Jianfei Shen, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai; Yaxing Shen and Qun Wang, Shanghai Zhongshan Hospital of Fudan University; Gening Jiang, Shanghai Pulmonary Hospital of Tongji University; Haiquan Chen, Fudan University Shanghai Cancer Center, Shanghai; Lunxu Liu, West China Hospital, Sichuan University, Chengdu; Shugeng Gao, Cancer Institute & Hospital, Chinese Academy of Medical Sciences; Shugeng Gao, Peking Union Medical College; Shugeng Gao, National Cancer Center; Deruo Liu, China and Japan Friendship Hospital; Xiuyi Zhi, Beijing Xuanwu Hospital of Capital Medical University; Bo Liu and Yixin Yang, Academy of Mathematics and Systems Science in the Chinese Academy of Sciences, Beijing; Zheng Wang, Shenzhen People's Hospital, Shenzhen; Calvin S.H. Ng, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region; Wensen Chen, Nanjing Medical University; Wensen Chen, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China; Chia-chuan Liu, Sun Yat-Sen Cancer Center, Taipei, Republic of China; René Horsleben Petersen, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark; Gaetano Rocco, Istituto Nazionale Tumori Fondazione G. Pascale, Naples, Italy; Thomas D'Amico, Duke University Medical Center, Durham, NC; and Alessandro Brunelli, St James's University Hospital, Leeds, United Kingdom.
First Affiliated Hospital of Guangzhou Medical University · CNMedtronic (Ireland) · IEJohnson & Johnson (United States) · USMedtronic (United States) · USJohnson & Johnson (Sweden) · SEGuangzhou Medical University · CN
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Abstract
Purpose We investigated the correlation between the number of examined lymph nodes (ELNs) and correct staging and long-term survival in non-small-cell lung cancer (NSCLC) by using large databases and determined the minimal threshold for the ELN count. Methods Data from a Chinese multi-institutional registry and the US SEER database on stage I to IIIA resected NSCLC (2001 to 2008) were analyzed for the relationship between the ELN count and stage migration and overall survival (OS) by using multivariable models. The series of the mean positive LNs, odds ratios (ORs), and hazard ratios (HRs) were fitted with a LOWESS smoother, and the structural break points were determined by Chow test. The selected cut point was validated with the SEER 2009 cohort. Results Although the distribution of ELN count differed between the Chinese registry (n = 5,706) and the SEER database (n = 38,806; median, 15 versus seven, respectively), both cohorts exhibited significantly proportional increases from N0 to N1 and N2 disease (SEER OR, 1.038; China OR, 1.012; both P < .001) and serial improvements in OS (N0 disease: SEER HR, 0.986; China HR, 0.981; both P < .001; N1 and N2 disease: SEER HR, 0.989; China HR, 0.984; both P < .001) as the ELN count increased after controlling for confounders. Cut point analysis showed a threshold ELN count of 16 in patients with declared node-negative disease, which were examined in the derivation cohorts (SEER 2001 to 2008 HR, 0.830; China HR, 0.738) and validated in the SEER 2009 cohort (HR, 0.837). Conclusion A greater number of ELNs is associated with more-accurate node staging and better long-term survival of resected NSCLC. We recommend 16 ELNs as the cut point for evaluating the quality of LN examination or prognostic stratification postoperatively for patients with declared node-negative disease.
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AgedCarcinoma, Non-Small-Cell LungChinaFemaleHumansLung NeoplasmsLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm StagingRegression AnalysisRetrospective StudiesSEER ProgramSurvival RateTime Factors
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