Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2017
Effects of Early Integrated Palliative Care in Patients With Lung and GI Cancer: A Randomized Clinical Trial.
2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 388 papers, 18 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
388citing papers in PubMed, 18 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Integration of Palliative and Supportive Care for Patients and Family Caregivers Undergoing Hematopoietic Stem Cell Transplantation or Chimeric Antigen Receptor T-Cell Therapy: A Prospective Pragmatic Randomized Clinical Trial
Web-based Symptom Monitoring and Survival in Advanced Stage Lung Cancer
Who cites it
388 citing papers in PubMed, 18 syntheses or guidelines pooled it.
- Integration of early palliative care in cancer treatment: a meta-analysis of 39 randomized controlled trials on clinical outcomes and management optimization.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- EASL position paper on palliative care in advanced chronic liver disease.JHEP reports : innovation in hepatology · 2026Guideline
- Palliative care interventions for thoracic cancer: a systematic review and meta-analysis identifying the core elements.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- A modelled cost-utility analysis comparing early referral to specialist palliative care versus standard care for older people with acute myeloid leukaemia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Impact of Depression on Mortality in Patients with Pancreatic Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2025Pooled it
- The benefits of early palliative care on psychological well-being, functional status, and health-related quality of life among cancer patients and their caregivers: a systematic review and meta-analysis.BMC palliative care · 2025Pooled it
- Pooled it
- Global research and emerging trends in depression in lung cancer: a bibliometric and visualized study from 2014 to 2024.Frontiers in oncology · 2025Pooled it
- Effect of applying digital health in palliative care for patients with advanced cancer: a meta-analysis and systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Primary palliative care in low- and middle-income countries: A systematic review and thematic synthesis of the evidence for models and outcomes.Palliative medicine · 2024Pooled it
- Screening instruments for early identification of unmet palliative care needs: a systematic review and meta-analysis.BMJ supportive & palliative care · 2024Pooled it
- Quality indicators for integrating oncology and home palliative care in Japan: modified Delphi study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Introduction of Various Models of Palliative Oncology Care: A Systematic Review.Reviews on recent clinical trials · 2024Pooled it
- Palliative Care Interventions Effects on Psychological Distress: A Systematic Review & Meta-Analysis.Journal of pain and symptom management · 2023Pooled it
- Effect of exercise interventions in adults with cancer receiving palliative care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Interventions for interpersonal communication about end of life care between health practitioners and affected people.The Cochrane database of systematic reviews · 2022Pooled it
- Pooled it
- Early palliative interventions for improving outcomes in people with a primary malignant brain tumour and their carers.The Cochrane database of systematic reviews · 2022Pooled it
- The ALLAN trial: impact of early home-based palliative care on emergency care and hospitalisation in advanced gastrointestinal cancer patients.British journal of cancer · 2026Trial
- Effect of a Symptom Surveillance and Collaborative Care Intervention on Palliative Care Utilization.Journal of pain and symptom management · 2026Trial
328 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors.
Jennifer S TemelJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Joseph A GreerJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Areej El-JawahriJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
William F PirlJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Elyse R ParkJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Vicki A JacksonJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Anthony L BackJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Mihir KamdarJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Juliet JacobsenJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Eva H ChittendenJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Simone P RinaldiJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Emily R GallagherJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Justin R EusebioJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Zhigang LiJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Alona MuzikanskyJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
David P RyanJennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Simone P. Rinaldi, Emily R. Gallagher, Justin R. Eusebio, Alona Muzikansky, and David P. Ryan, Massachusetts General Hospital; Jennifer S. Temel, Joseph A. Greer, Areej El-Jawahri, William F. Pirl, Elyse R. Park, Vicki A. Jackson, Mihir Kamdar, Juliet Jacobsen, Eva H. Chittenden, Alona Muzikansky, and David P. Ryan, Harvard Medical School, Boston, MA; Anthony L. Back, University of Washington, Seattle, WA; and Zhigang Li, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MA Randomized trial of early palliative care for newly diagnosed cancer patientsR01NR012735 · NINR · MASSACHUSETTS GENERAL HOSPITAL · PI TEMEL, JENNIFER SUE · 2011 to 2015
$2.1MNCI NIH HHS P30 CA023108NINR NIH HHS R01 NR012735
Abstract
Purpose We evaluated the impact of early integrated palliative care (PC) in patients with newly diagnosed lung and GI cancer. Patients and Methods We randomly assigned patients with newly diagnosed incurable lung or noncolorectal GI cancer to receive either early integrated PC and oncology care (n = 175) or usual care (n = 175) between May 2011 and July 2015. Patients who were assigned to the intervention met with a PC clinician at least once per month until death, whereas those who received usual care consulted a PC clinician upon request. The primary end point was change in quality of life (QOL) from baseline to week 12, per scoring by the Functional Assessment of Cancer Therapy-General scale. Secondary end points included change in QOL from baseline to week 24, change in depression per the Patient Health Questionnaire-9, and differences in end-of-life communication. Results Intervention patients ( v usual care) reported greater improvement in QOL from baseline to week 24 (1.59 v -3.40; P = .010) but not week 12 (0.39 v -1.13; P = .339). Intervention patients also reported lower depression at week 24, controlling for baseline scores (adjusted mean difference, -1.17; 95% CI, -2.33 to -0.01; P = .048). Intervention effects varied by cancer type, such that intervention patients with lung cancer reported improvements in QOL and depression at 12 and 24 weeks, whereas usual care patients with lung cancer reported deterioration. Patients with GI cancers in both study groups reported improvements in QOL and mood by week 12. Intervention patients versus usual care patients were more likely to discuss their wishes with their oncologist if they were dying (30.2% v 14.5%; P = .004). Conclusion For patients with newly diagnosed incurable cancers, early integrated PC improved QOL and other salient outcomes, with differential effects by cancer type. Early integrated PC may be most effective if targeted to the specific needs of each patient population.
Indexed as
AgedCombined Modality TherapyDepressionFemaleGastrointestinal NeoplasmsHumansLung NeoplasmsMaleMiddle AgedPalliative CareQuality of Life
Identifiers
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Read underepoch 390
Registered trials
NCT05190653ClinicalTrials.gov
NCT05621902ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.