ReviewMolecules (Basel, Switzerland)2016
The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview.
Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 344 citations in OpenAlex.
- Cyclodextrins as Active Therapeutic Agents: Beyond Their Role as Excipients.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The Potential of Amphiphilic Cyclodextrins as Carriers for Therapeutic Purposes: A Short Overview.Pharmaceutics · 2025Review
- Design, characterization, andRSC advances · 2025Article
- Preparation, characterization, and in vitro cytogenotoxic evaluation of a novel dimenhydrinate-β-cyclodextrin inclusion complex.Biomolecules & biomedicine · 2024Article
- Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study.International journal of molecular sciences · 2024Article
- Current Challenges and Opportunities for Improved Cannabidiol Solubility.International journal of molecular sciences · 2023Article
- Hydroxypropyl-β-Cyclodextrin Depletes Membrane Cholesterol and Inhibits SARS-CoV-2 Entry into HEK293T-ACEPathogens (Basel, Switzerland) · 2023Article
- Mass Spectrometric Evaluation of β-Cyclodextrins as Potential Hosts for Titanocene Dichloride.International journal of molecular sciences · 2021Article
- Clinically translatable formulation strategies for systemic administration of nerve-specific probes.Advanced therapeutics · 2021Article
- A pH sensitive thiolated β-cyclodextrin-modified nanoporous gold for controlled release of doxorubicin.Journal of drug delivery science and technology · 2020Article
- New Formulation of a Methylseleno-Aspirin Analog with Anticancer Activity towards Colon Cancer.International journal of molecular sciences · 2020Article
- The Budesonide-Hydroxypropyl-β-Cyclodextrin Complex Attenuates ROS Generation, IL-8 Release and Cell Death Induced by Oxidant and Inflammatory Stress. Study on A549 and A-THP-1 Cells.Molecules (Basel, Switzerland) · 2020Article
- Noncovalent Complexes of Cyclodextrin with Small Organic Molecules: Applications and Insights into Host-Guest Interactions in the Gas Phase and Condensed Phase.Molecules (Basel, Switzerland) · 2020Review
- Citric acid-crosslinked β-cyclodextrin supported zinc peroxide as a biocompatible HJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2020Article
- Physicochemical Characterization and Antioxidant Activity Evaluation of Idebenone/Hydroxypropyl-Biomolecules · 2019Article
- Cyclodextrins reduce the ability of Pseudomonas aeruginosa outer-membrane vesicles to reduce CFTR ClAmerican journal of physiology. Lung cellular and molecular physiology · 2019Article
- Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment.Molecules (Basel, Switzerland) · 2018Review
- DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination.Frontiers in immunology · 2018Article
- Photosensitive drugs: a review on their photoprotection by liposomes and cyclodextrins.Drug delivery · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclodextrins (CDs) are cyclic oligosaccharides of natural origin that were discovered more than 100 years ago. The peculiar cone-like conformation of the sugar ring, expressing a lipophilic cavity and a hydrophilic external surface, allows these substances to spontaneously complex poorly soluble compounds in an aqueous environment. For more than 50 years, these substances have found applicability in the pharmaceutical and food industries as solubilizing agents for poorly soluble chemical entities. Nowadays, several research groups all over the world are investigating their potential as active pharmaceutical ingredients (APIs) for the treatment of several illnesses (e.g., hypercholesterolemia, cancer, Niemann-Pick Type C disease). The aim of this review is to briefly retrace cyclodextrins' legacy as complexing agents and describe the current and future prospects of this class of chemical entities in pharmaceutics as new APIs.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.