Evidence map›Paper›PMID 28029135›Full record

ReviewMolecules (Basel, Switzerland)2016

Time-Resolved Fluorescence Spectroscopy and Fluorescence Lifetime Imaging Microscopy for Characterization of Dendritic Polymer Nanoparticles and Applications in Nanomedicine.

Alexander Boreham, Robert Brodwolf, Karolina Walker, Rainer Haag, Ulrike Alexiev

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander BorehamInstitut für Experimentalphysik, Freie Universität Berlin, Arnimallee 14, 14195 Berlin, Germany. alexander.boreham@fu-berlin.de.
Robert BrodwolfInstitut für Experimentalphysik, Freie Universität Berlin, Arnimallee 14, 14195 Berlin, Germany. brodwolf@zedat.fu-berlin.de.
Karolina WalkerInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany. karolina.walker@fu-berlin.de.
Rainer HaagInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany. haag@zedat.fu-berlin.de.
Ulrike AlexievInstitut für Experimentalphysik, Freie Universität Berlin, Arnimallee 14, 14195 Berlin, Germany. ulrike.alexiev@fu-berlin.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emerging field of nanomedicine provides new approaches for the diagnosis and treatment of diseases, for symptom relief and for monitoring of disease progression. One route of realizing this approach is through carefully constructed nanoparticles. Due to the small size inherent to the nanoparticles a proper characterization is not trivial. This review highlights the application of time-resolved fluorescence spectroscopy and fluorescence lifetime imaging microscopy (FLIM) for the analysis of nanoparticles, covering aspects ranging from molecular properties to particle detection in tissue samples. The latter technique is particularly important as FLIM allows for distinguishing of target molecules from the autofluorescent background and, due to the environmental sensitivity of the fluorescence lifetime, also offers insights into the local environment of the nanoparticle or its interactions with other biomolecules. Thus, these techniques offer highly suitable tools in the fields of particle development, such as organic chemistry, and in the fields of particle application, such as in experimental dermatology or pharmaceutical research.

Indexed as

DendrimersDrug CompoundingDrug LiberationFluorescence PolarizationFluorescent DyesMicroscopy, FluorescenceNanomedicineNanoparticlesParticle SizeSpectrometry, FluorescenceTime-Lapse ImagingDendrimersFluorescent Dyesdendritic nanoparticlesFLIMfluorescence lifetime imaging microscopynanomedicinetime-resolved fluorescence depolarization

Identifiers

PMID28029135
PMCPMC6155873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.