Trial reportNutrients2016
Folate and Vitamin B
Trial report in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 27 citations in OpenAlex.
- Vitamin B12, Homocysteine and Cognitive Impairment in Elderly Patients with Type 2 Diabetes.Journal of clinical medicine · 2026Article
- Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Increased serum methylmalonic acid levels were associated with the presence of cognitive dysfunction in older chronic kidney disease patients with albuminuria.BMC geriatrics · 2024Article
- Neurovascular Correlates of Cobalamin, Folate, and Homocysteine in Dementia.Journal of Alzheimer's disease : JAD · 2023Article
- The Role of Micronutrients in Ageing Asia: What Can Be Implemented with the Existing Insights.Nutrients · 2021Review
- Alzheimer's Disease and Diabetes: Role of Diet, Microbiota and Inflammation in Preclinical Models.Biomolecules · 2021Review
- Serum vitamin BThe British journal of nutrition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimWe investigated cross-sectional associations between circulating homocysteine, folate, biomarkers of vitamin B
methodsParticipants of the B-PROOF study (
resultsMultiple linear regression analyses showed inverse associations between plasma homocysteine with TBV (β = -0.91, 95% CI -1.85-0.03;
conclusionsResults were contradictory, with higher Hcy levels associated with lower TBV, but also with higher folate levels associated with lower TBV. In addition, the lack of a baseline measurement withholds us from giving recommendations on whether folic acid and vitamin B
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.