Evidence map›Paper›PMID 28028785›Full record

ArticleJournal of endocrinological investigation2017

Disturbed nitric oxide and homocysteine production are involved in the increased risk of cardiovascular diseases in the F1 offspring of maternal obesity and malnutrition.

Y Y Moussa, S H Tawfik, M M Haiba, M I Saad, M Y Hanafi, T M Abdelkhalek, G A Oriquat, M A Kamel

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In one paragraph

Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Y Y MoussaDepartment of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.
S H TawfikMolecular Medicine Department, Padova University, Padua, Italy.
M M HaibaDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
M I SaadDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt. m.ibrahim1988@hotmail.com.
M Y HanafiDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
T M AbdelkhalekDepartment of Human Genetics, Medical Research Institute, Alexandria University, Alexandria, Egypt.
G A OriquatFaculty of Pharmacy and Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.
M A KamelDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Alexandria University · EGAl-Ahliyya Amman University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe present study aimed to evaluate the changes in levels of different independent risk factors for vascular diseases in the rat offspring of maternal obesity and malnutrition as maternal health disturbances are thought to have direct consequences on the offspring health. The effect of postnatal diet on the offspring was also assessed.

methodsThree groups of female Wistar rats were used (control, obese and malnourished). After the pregnancy and delivery, the offspring were weaned to control diet or high-caloric (HCD) diet and followed up for 30 weeks. Every 5 weeks postnatal, 20 pups (10 males and 10 females) of each subgroup were sacrificed after overnight fasting, the blood sample was obtained, and the rats were dissected out to obtain heart muscle. The following parameters were assessed; lipid profile, NEFA, homocysteine (Hcy), nitric oxide end product (NOx) and myocardial triglyceride content.

resultsMaternal obesity and malnutrition caused significant elevation in the body weight, triglycerides, NEFA, Hcy and NOx in the F1 offspring especially those maintained under HCD. Also, the male offspring showed more prominent changes than female offspring.

conclusionsMaternal malnutrition and obesity may increase the risk of the development of cardiovascular diseases in the offspring, especially the male ones.

Indexed as

AnimalsAnimals, NewbornCardiovascular DiseasesFemaleHomocysteineMalnutritionNitric OxideObesityPregnancyPrenatal Exposure Delayed EffectsRatsRats, WistarHomocysteineNitric OxideDiabetesFetal reprogrammingMalnutritionObesity

Identifiers

PMID28028785
OpenAlexW2567050658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.