ArticleJournal of neurology2017
Migraine causes retinal and choroidal structural changes: evaluation with ocular coherence tomography.
Article in Journal of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Retinal nerve fiber layer changes in migraine: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Optical coherence tomography is a useful tool for monitoring treatment response in migraine: a prospective longitudinal study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Clinical Characteristics of Migraine and Their Association With the Retinal Nerve Fiber Layer Thickness.Cureus · 2024Article
- Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review.Frontiers in neuroscience · 2024Review
- Article
- Microvascular involvement in migraine: an optical coherence tomography angiography study.Journal of neurology · 2023Article
- L-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial).BMC neurology · 2023Article
- Decrease Retinal Thickness in Patients with Chronic Migraine Evaluated by Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2022Article
- Evaluation of migraine patients with optical coherence tomography angiography.International ophthalmology · 2021Article
- Visual Evoked Potential Responses after Photostress in Migraine Patients and Their Correlations with Clinical Features.Journal of clinical medicine · 2021Article
- Evaluation of retinal vessel density and choriocapillaris flow in migraine patients with and without aura.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Regional volume changes of the brain in migraine chronification.Neural regeneration research · 2020Article
- Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study.Antioxidants (Basel, Switzerland) · 2020Article
- Altered Macular Vasculature in Migraine Patients without Aura: Is It Associated with Ocular Vasculature and White Matter Hyperintensities?Journal of ophthalmology · 2020Article
- Retinal correlates of neurological disorders.Therapeutic advances in chronic disease · 2019Review
- Association of Meniere's disease and retinal vascular calibre: a prospective observational study in China.BMJ open · 2018Observational
- Idiopathic Intracranial Hypertension Without Papilledema (IIHWOP) in Chronic Refractory Headache.Frontiers in neurology · 2018Article
- Optical Coherence Tomography in Patients with Chronic Migraine: Literature Review and Update.Frontiers in neurology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few studies have evaluated whether the retina is involved in migraine through the evaluation of retinal nerve fiber layer (RNFL) examined with ocular coherence tomography (OCT) with conflicting results. Aim of this case-control study is to evaluate the retina and the choroid in migraine. Patients having migraine with aura (MwA) or without aura (MoA) and chronic migraine (CM) were evaluated. Age- and sex-matched normal subjects were selected as healthy controls (HC). Patients and HC were examined with OCT. RNFL, ganglion cell layer (GCL), foveal thickness (FT), choroidal thickness (CT) and total macular volume (TMV) were calculated for right eyes (RE) and left eyes (LE). Seventy-seven patients (62 women; 80.5%), 21 MoA, 12 MwA, 44 CM and 42 HC were enrolled in the study. Patients compared to HC had a significant reduction of RNFL (RE: 91.2 ± 9.2 vs 99.3 ± 7.5 μm; p < 0.001. LE: 93.3 ± 8.7 vs 100.2 ± 6.5 μm; p < 0.001). GCL (RE: 80.6 ± 6.4 vs 86.9 ± 2.1 μm; p < 0.0001. LE: 81.5 ± 5.7 vs 87.1 ± 2.6 μm; p < 0.0001) and CT (RE: 286.4 ± 31.4 vs 333.2 ± 3.1 μm; p < 0.0001. LE: 287.2 ± 31.6 vs 334.5 ± 4.1 μm; p < 0.0001) were thinner in patients compared to HC. Moreover, CM showed reduction of RNFL and of GCL compared to the other migraineurs. Finally, we found a significant inverse correlation between RNFL thickness and total number of headache attacks per months. Our data suggest the involvement of retina and choroid in migraineurs, especially in the CM group. Although migraine is an episodic and recurrent disease, its chronic nature might cause permanent structural abnormalities involving not only the brain, but also the retina.
Indexed as
Identifiers
28028626What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.