Evidence map›Paper›PMID 28028606›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2018

Novelty seeking mediates the effect of DRD3 variation on onset age of amphetamine dependence in Han Chinese population.

Shin-Chang Kuo, Yi-Wei Yeh, Chun-Yen Chen, Chang-Chih Huang, Tien-Yu Chen, Che-Hung Yen, Chih-Sung Liang, Pei-Shen Ho, Ru-Band Lu, San-Yuan Huang

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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Shin-Chang KuoGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.
Yi-Wei YehGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.
Chun-Yen ChenGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.
Chang-Chih HuangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.
Tien-Yu ChenDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road, Sec. 2, Nei-Hu District, Taipei, 144, Taiwan, ROC.
Che-Hung YenGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.
Chih-Sung LiangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.
Pei-Shen HoDepartment of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Ru-Band LuInstitute of Behavior Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
San-Yuan HuangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, ROC. hsy@ndmctsgh.edu.tw.
Tri-Service General Hospital · TWNational Defense Medical Center · TWNational Cheng Kung University · TW

Funding

Medical Affairs Bureau, Ministry of National Defense, Taiwan MAB-104-073National Science Council MOST-103-2325-B-016-001National Science Council MOST-104-2314-B-016-012MY3National Science Council NSC101-2325-B-016-003Tri-Service General Hospital TSGH-C103-133Tri-Service General Hospital TSGH-C104-126Tri-Service General Hospital TSGH-C104-129Tri-Service General Hospital TSGH-C105-124Tri-Service General Hospital TSGH-C105-125
6 · The paper itself

Abstract

The dopamine receptor D3 (DRD3) gene, one of the candidate genes for amphetamine dependence (AD), is involved in the mesolimbic dopaminergic system, implicated as the underlying mechanism of addiction. Our case-control study aimed to investigate whether the DRD3 gene is associated with the susceptibility to AD and specific personality traits in AD patients. A total of 1060 unrelated Han Chinese subjects (559 AD patients and 501 controls) were screened using the same assessment tool and genotyped for eight DRD3 polymorphisms. All patients met the DSM-IV-TR criteria for AD, and personality traits of 539 were assessed using a Tridimensional Personality Questionnaire. Furthermore, AD individuals were divided into four clinical subgroups based on gender and psychosis status, to reduce the clinical heterogeneity. We found that the ATA haplotype combination for SNPs rs324029, rs6280, and rs9825563, respectively, was significantly associated with total AD patients (p = 0.0003 after 10,000 permutations). Similar results were observed in the both male and non-psychosis subgroup but not in other subgroups. In addition, DRD3 rs9825563 may influence onset age of drug use, partially mediated by novelty seeking in the non-psychosis AD group. In conclusion, DRD3 is a potential genetic factor in the susceptibility to AD and is associated with onset age of drug use through interaction with novelty seeking in a specific patient group in the Han Chinese population.

Indexed as

Drug-Seeking BehaviorAdultAge of OnsetAmphetamine-Related DisordersAsian PeopleFemaleGenotypeHumansLogistic ModelsMaleMiddle AgedPersonalityPersonality InventoryPolymorphism, Single NucleotideReceptors, Dopamine D3Retrospective StudiesDRD3 protein, humanReceptors, Dopamine D3Amphetamine dependenceDRD3 geneOnset agePersonality trait

Identifiers

PMID28028606
OpenAlexW2566499421

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.