Evidence map›Paper›PMID 28028601›Full record

ArticlePsychopharmacology2017

Voluntary inhalation of methamphetamine: a novel strategy for studying intake non-invasively.

C Juarez-Portilla, R D Kim, M Robotham, M Tariq, M Pitter, J LeSauter, R Silver

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Investigating the sequential patterns of methamphetamine use initiation in Iran.Substance abuse treatment, prevention, and policy · 2020
    Article
  3. Article
  4. Compulsive-Like Sufentanil Vapor Self-Administration in Rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

C Juarez-PortillaCentro de Investigaciones Biomédicas, Universidad Veracruzana, Veracruz, Mexico.
R D KimNeuroscience Program and Department of Psychology, Barnard College of Columbia University, New York, NY, 10027, USA.
M RobothamNeuroscience Program and Department of Psychology, Barnard College of Columbia University, New York, NY, 10027, USA.
M TariqNeuroscience Program and Department of Psychology, Barnard College of Columbia University, New York, NY, 10027, USA.
M PitterNeuroscience Program and Department of Psychology, Barnard College of Columbia University, New York, NY, 10027, USA.
J LeSauterNeuroscience Program and Department of Psychology, Barnard College of Columbia University, New York, NY, 10027, USA.
R SilverNeuroscience Program and Department of Psychology, Barnard College of Columbia University, New York, NY, 10027, USA. QR@columbia.edu.
Columbia University · USUniversidad Veracruzana · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleThe abuse of the psychostimulant methamphetamine (MA) is associated with substantial costs and limited treatment options. To understand the mechanisms that lead to abuse, animal models of voluntary drug intake are crucial.

objectivesWe aimed to develop a protocol to study long-term non-invasive voluntary intake of MA in mice.

methodsMice were maintained in their home cages and allowed daily 1 h access to an attached tunnel leading to a test chamber in which nebulized MA was available. Restated, if they went to the nebulizing chamber, they self-administered MA by inhalation. This protocol was compared to injected and to imposed exposure to nebulized MA, in a series of seven experiments.

resultsWe established a concentration of nebulized MA at which motor activity increases following voluntary intake resembled that following MA injection and imposed inhalation. We found that mice regulated their exposure to MA, self-administering for shorter durations when concentrations of nebulized MA were increased. Mice acquire the available MA by repeatedly running in and out of the nebulizing chamber for brief bouts of intake. Such exposure to nebulized MA elevated plasma MA levels. There was limited evidence of sensitization of locomotor activity. Finally, blocking access to the wheel did not affect time spent in the nebulizing chamber.

conclusionsWe conclude that administration of MA by nebulization is an effective route of self-administration, and our new protocol represents a promising tool for examining the transitions from first intake to long-term use and its behavioral and neural consequences in a non-invasive protocol.

Indexed as

Administration, InhalationSelf AdministrationAnimalsBehavior, AnimalCentral Nervous System StimulantsMaleMethamphetamineMiceModels, AnimalMotor ActivityNebulizers and VaporizersRunningTime FactorsCentral Nervous System StimulantsMethamphetamineAddictionNasal administrationNebulizationNon-invasiveSelf-administrationSensitizationVoluntary intake

Identifiers

PMID28028601
OpenAlexW2561063447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.