Evidence map›Paper›PMID 28028565›Full record

Observational studyNeuroradiology2017

Severe cerebral hypovolemia on perfusion CT and lower body weight are associated with parenchymal haemorrhage after thrombolysis.

S Tsetsou, M Amiguet, A Eskandari, R Meuli, P Maeder, B Jiang, M Wintermark, P Michel

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

S TsetsouDepartment of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland. stsetsou@hotmail.com.ORCID http://orcid.org/0000-0003-4521-5745
M AmiguetInstitute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
A EskandariDepartment of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
R MeuliDepartment of Radiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
P MaederDepartment of Radiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
B JiangDepartment of Radiology, Neuroradiology Division, Stanford University and Medical Center, Stanford, CA, USA.
M WintermarkDepartment of Radiology, Neuroradiology Division, Stanford University and Medical Center, Stanford, CA, USA.
P MichelDepartment of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
University Hospital of Lausanne · CHStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHaemorrhagic transformation of acute ischemic stroke (AIS) and particularly parenchymal haemorrhage (PH) remains a feared complication of intravenous thrombolysis (IVT). We aimed to identify clinical and perfusion CT (PCT) variables which are independently associated with PHs.

methodsIn this observational cohort study, based on the Acute Stroke Registry Analysis of Lausanne (ASTRAL) from 2003 to December 2013, we selected patients with AIS involving the middle cerebral artery (MCA) territory who were thrombolysed within 4.5 h of symptoms' onset and who had a good quality baseline PCT at the beginning of IVT. In addition to demographic, clinical, laboratory and non-contrast CT data, volumes of salvageable tissue and ischemic core on PCT, as well as absolute CBF and CBV values within the ischemic regions were compared in patients with and without PH in multivariate analysis.

resultsOf the 190 included patients, 24 (12.6%) presented a PH (11 had PH1 and 13 had PH2). In multivariate analysis of the clinical and radiological variables, the lowest CBV in the core and lower body weight was both significantly associated with PH (p = 0.009 and p = 0.024, respectively).

conclusionIn thrombolysed MCA strokes, maximal hypoperfusion severity depicted by lowest CBV values in the core region and lower body weight are independently correlated with PH. This information, if confirmed in other case series, may add to the stratification of revascularisation decisions in patients with a perceived high PH risk.

Indexed as

Body WeightCerebrovascular CirculationAgedCerebral AngiographyCerebral HemorrhageContrast MediaFemaleHumansHypovolemiaIohexolMagnetic Resonance AngiographyMaleRegistriesRisk FactorsStrokeThrombolytic TherapyContrast MediaIohexolParenchymal haemorrhagePerfusion CTStroke

Identifiers

PMID28028565
OpenAlexW2564789736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.