Evidence map›Paper›PMID 28028552›Full record

Trial reportIntensive care medicine2017

Venous thromboembolic events in critically ill traumatic brain injury patients.

Markus B Skrifvars, Michael Bailey, Jeffrey Presneill, Craig French, Alistair Nichol, Lorraine Little, Jacques Duranteau, Olivier Huet, Samir Haddad, Yaseen Arabi and 4 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 5 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Pooled it
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  6. Trial
  7. Article
  8. Article
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  12. Rinaldo Bellomo's contribution to trauma and traumatic brain injury research.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025
    Review
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  14. Review
  15. Venous thromboembolism chemoprophylaxis in geriatric trauma patients with isolated severe traumatic brain injury.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
  16. Article
  17. Early administration of high dose enoxaparin after traumatic brain injury.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 6 countries.

Markus B SkrifvarsAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 55 Commercial Rd, Melbourne, VIC, 3004, Australia. markus.skrifvars@monash.edu.
Michael BaileyAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 55 Commercial Rd, Melbourne, VIC, 3004, Australia.
Jeffrey PresneillAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 55 Commercial Rd, Melbourne, VIC, 3004, Australia.
Craig FrenchDepartment of Intensive Care, Western Health, Melbourne, VIC, Australia.
Alistair NicholAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 55 Commercial Rd, Melbourne, VIC, 3004, Australia.
Lorraine LittleAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 55 Commercial Rd, Melbourne, VIC, 3004, Australia.
Jacques DuranteauDépartement d'Anesthésie-Réanimation, Hôpital de Bicêtre, Assistance Publique des Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Paris, France.
Olivier HuetDepartment of Anaesthesiology and Intensive Care Medicine, CHRU La Cavale Blanche, Université de Bretagne Occidentale, Brest, France.
Samir HaddadKing Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Yaseen ArabiKing Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Colin McArthurDepartment of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand.
D James CooperAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 55 Commercial Rd, Melbourne, VIC, 3004, Australia.
Rinaldo BellomoAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 55 Commercial Rd, Melbourne, VIC, 3004, Australia.
EPO-TBI investigators and the ANZICS Clinical Trials Group
Monash University · AUAlfred Health · AUAuckland City Hospital · NZAustin Health · AUKing Abdullah International Medical Research Center · SAKing Saud bin Abdulaziz University for Health Sciences · SAThe University of Melbourne · AUUniversité de Bretagne Occidentale · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo estimate the prevalence, risk factors, prophylactic treatment and impact on mortality for venous thromboembolism (VTE) in patients with moderate to severe traumatic brain injury (TBI) treated in the intensive care unit.

methodsA post hoc analysis of the erythropoietin in traumatic brain injury (EPO-TBI) trial that included twice-weekly lower limb ultrasound screening. Venous thrombotic events were defined as ultrasound-proven proximal deep venous thrombosis (DVT) or clinically detected pulmonary embolism (PE). Results are reported as events, percentages or medians and interquartile range (IQR). Cox regression analysis was used to calculate adjusted hazard ratios (HR) with 95% confidence intervals (CI) for time to VTE and death.

resultsOf 603 patients, 119 (19.7%) developed VTE, mostly comprising DVT (102 patients, 16.9%) with a smaller number of PE events (24 patients, 4.0%). Median time to DVT diagnosis was 6 days (IQR 2-11) and to PE diagnosis 6.5 days (IQR 2-16.5). Mechanical prophylaxis (MP) was used in 91% of patients on day 1, 97% of patients on day 3 and 98% of patients on day 7. Pharmacological prophylaxis was given in 5% of patients on day 1, 30% of patients on day 3 and 57% of patients on day 7. Factors associated with time to VTE were age (HR per year 1.02, 95% CI 1.01-1.03), patient weight (HR per kg 1.01, 95% CI 1-1.02) and TBI severity according to the International Mission for Prognosis and Analysis of Clinical Trials risk of poor outcome (HR per 10% increase 1.12, 95% CI 1.01-1.25). The development of VTE was not associated with mortality (HR 0.92, 95% CI 0.51-1.65).

conclusionsDespite mechanical and pharmacological prophylaxis, VTE occurs in one out of every five patients with TBI treated in the ICU. Higher age, greater weight and greater severity of TBI increase the risk. The development of VTE was not associated with excess mortality.

Indexed as

AdultBrain Injuries, TraumaticCritical IllnessFollow-Up StudiesHumansIntensive Care UnitsMaleMiddle AgedPrevalencePulmonary EmbolismRegression AnalysisRisk FactorsSeverity of Illness IndexStatistics, NonparametricUltrasonography, DopplerVenous ThromboembolismDeep venous thrombosisErythropoietinPulmonary embolismTraumatic brain injuryVenous thromboembolism

Identifiers

PMID28028552
OpenAlexW2562481671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.