ArticleScience advances2016
Cellular uptake and dynamics of unlabeled freestanding silicon nanowires.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Biomimetic graphitic carbon nitride nanoparticles for multiscale photomodulation and therapeutic intervention.Nature biomedical engineering · 2026Article
- Illuminating the Underlying Mechanism of Intracellular Optoelectronic Modulation Using Silicon Nanowires.ACS nano · 2025Article
- Three-dimensional cellular construct with impregnated silicon nanowires for intracellular optoelectronic biointerface.Materials today. Bio · 2025Article
- Charge Capacitive Signatures at the Interface of E. coli/MOF Biohybrids to Create a Live Cell Biocapacitor.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Antimicrobial peptide-conjugated phage-mimicking nanoparticles exhibit potent bactericidal action againstNanoscale advances · 2024Article
- Article
- Nanowired human cardiac organoid transplantation enables highly efficient and effective recovery of infarcted hearts.Science advances · 2023Article
- Morphological transformations of vesicles with confined flexible filaments.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Bio-hybrid electronic and photonic devices.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Differential modulation of endothelial cytoplasmic protrusions after exposure to graphene-family nanomaterials.NanoImpact · 2022Article
- The use of advanced spectral imaging to reveal nanoparticle identity in biological samples.Nanoscale · 2022Article
- Dissecting Biological and Synthetic Soft-Hard Interfaces for Tissue-Like Systems.Chemical reviews · 2022Review
- Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires.Nature communications · 2022Article
- Morphological Factors that Underlie Neural Sensitivity to Stimulation in the Retina.Advanced nanobiomed research · 2021Article
- Nanoenabled Bioelectrical Modulation.Accounts of materials research · 2021Article
- Tutorial: using nanoneedles for intracellular delivery.Nature protocols · 2021Review
- Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood-brain barrier model.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Direct Observations of Silver Nanowire-Induced Frustrated Phagocytosis among NR8383 Lung Alveolar Macrophages.The journal of physical chemistry. B · 2020Article
- Interactions at engineered graft-tissue interfaces: A review.APL bioengineering · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The ability to seamlessly merge electronic devices with biological systems at the cellular length scale is an exciting prospect for exploring new fundamental cell biology and in designing next-generation therapeutic devices. Semiconductor nanowires are well suited for achieving this goal because of their intrinsic size and wide range of possible configurations. However, current studies have focused primarily on delivering substrate-bound nanowire devices through mechanical abrasion or electroporation, with these bulkier substrates negating many of the inherent benefits of using nanoscale materials. To improve on this, an important next step is learning how to distribute these devices in a drug-like fashion, where cells can naturally uptake and incorporate these electronic components, allowing for truly noninvasive device integration. We show that silicon nanowires (SiNWs) can potentially be used as such a system, demonstrating that label-free SiNWs can be internalized in multiple cell lines (96% uptake rate), undergoing an active "burst-like" transport process. Our results show that, rather than through exogenous manipulation, SiNWs are internalized primarily through an endogenous phagocytosis pathway, allowing cellular integration of these materials. To study this behavior, we have developed a robust set of methodologies for quantitatively examining high-aspect ratio nanowire-cell interactions in a time-dependent manner on both single-cell and ensemble levels. This approach represents one of the first dynamic studies of semiconductor nanowire internalization and offers valuable insight into designing devices for biomolecule delivery, intracellular sensing, and photoresponsive therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.